Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin? - PubMed (original) (raw)
Clinical Trial
Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin?
E Doucet et al. J Clin Endocrinol Metab. 2000 Apr.
Abstract
The aim of the present study was to determine the impact of weight loss and its related metabolic and hormonal changes on resting energy expenditure (REE) and substrate oxidation. Forty subjects (16 men and 24 women) took part in a 15-week weight loss program that consisted of drug therapy (fenfluramine, 60 mg/day) or placebo coupled to an energy restriction (-700 Cal/day). Subjects were asked to come to the laboratory after an overnight fast for an indirect calorimetry measurement before and after weight loss. Fasting blood samples were also drawn and were analyzed for plasma glucose, insulin, leptin, and free fatty acid determinations. This program reduced body weight by 11% and 9% (P < 0.01) in men and women, respectively. Fat mass (FM) and fat-free mass (FFM) were also significantly reduced in both sexes. A significant decrease in REE (13%; P < 0.01) and fat oxidation (11%; P = 0.08) was observed in men in response to this program, whereas no significant differences were noted for these variables in women. In men, positive correlations were found between changes in FFM and energy-related variables, whereas the best predictor of changes in REE and substrate oxidation was the change in FM in women. The most important finding of this study is that in men, the association between changes in fasting plasma leptin and changes in REE (r = 0.50; P < 0.01) and fat oxidation (r = 0.63; P < 0.01) persist after correction for changes in body composition. These results suggest that a comparable weight loss is accompanied by a greater decrease in REE and substrate oxidation in men than in women, and that these changes are better explained by changes in leptinemia in men and by changes in FM in women.
Similar articles
- Changes in leptin and peptide YY do not explain the greater-than-predicted decreases in resting energy expenditure after weight loss.
McNeil J, Schwartz A, Rabasa-Lhoret R, Lavoie JM, Brochu M, Doucet É. McNeil J, et al. J Clin Endocrinol Metab. 2015 Mar;100(3):E443-52. doi: 10.1210/jc.2014-2210. Epub 2014 Dec 12. J Clin Endocrinol Metab. 2015. PMID: 25494860 Clinical Trial. - Fasting insulin levels influence plasma leptin levels independently from the contribution of adiposity: evidence from both a cross-sectional and an intervention study.
Doucet E, St-Pierre S, Alméras N, Mauriège P, Després JP, Richard D, Bouchard C, Tremblay A; Quebec Family Study. Doucet E, et al. J Clin Endocrinol Metab. 2000 Nov;85(11):4231-7. doi: 10.1210/jcem.85.11.6980. J Clin Endocrinol Metab. 2000. PMID: 11095459 Clinical Trial. - Relationship between energy expenditure and visceral fat accumulation in obese women submitted to adjustable silicone gastric banding (ASGB).
Busetto L, Perini P, Giantin V, Valente P, Segato G, Belluco C, Favretti F, Enzi G. Busetto L, et al. Int J Obes Relat Metab Disord. 1995 Apr;19(4):227-33. Int J Obes Relat Metab Disord. 1995. PMID: 7627245 Clinical Trial. - Deep body composition phenotyping during weight cycling: relevance to metabolic efficiency and metabolic risk.
Bosy-Westphal A, Kahlhöfer J, Lagerpusch M, Skurk T, Müller MJ. Bosy-Westphal A, et al. Obes Rev. 2015 Feb;16 Suppl 1:36-44. doi: 10.1111/obr.12254. Obes Rev. 2015. PMID: 25614202 Review. - Changes in Energy Expenditure with Weight Gain and Weight Loss in Humans.
Müller MJ, Enderle J, Bosy-Westphal A. Müller MJ, et al. Curr Obes Rep. 2016 Dec;5(4):413-423. doi: 10.1007/s13679-016-0237-4. Curr Obes Rep. 2016. PMID: 27739007 Free PMC article. Review.
Cited by
- Timeline of changes in adaptive physiological responses, at the level of energy expenditure, with progressive weight loss.
Nymo S, Coutinho SR, Torgersen LH, Bomo OJ, Haugvaldstad I, Truby H, Kulseng B, Martins C. Nymo S, et al. Br J Nutr. 2018 Jul;120(2):141-149. doi: 10.1017/S0007114518000922. Epub 2018 May 7. Br J Nutr. 2018. PMID: 29733003 Free PMC article. - Weight Loss and Appetite Control in Women.
Hintze LJ, Mahmoodianfard S, Auguste CB, Doucet É. Hintze LJ, et al. Curr Obes Rep. 2017 Sep;6(3):334-351. doi: 10.1007/s13679-017-0273-8. Curr Obes Rep. 2017. PMID: 28762102 Review. - Does the method of weight loss effect long-term changes in weight, body composition or chronic disease risk factors in overweight or obese adults? A systematic review.
Washburn RA, Szabo AN, Lambourne K, Willis EA, Ptomey LT, Honas JJ, Herrmann SD, Donnelly JE. Washburn RA, et al. PLoS One. 2014 Oct 15;9(10):e109849. doi: 10.1371/journal.pone.0109849. eCollection 2014. PLoS One. 2014. PMID: 25333384 Free PMC article. Review. - Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later?
Izquierdo AG, Crujeiras AB, Casanueva FF, Carreira MC. Izquierdo AG, et al. Nutrients. 2019 Nov 8;11(11):2704. doi: 10.3390/nu11112704. Nutrients. 2019. PMID: 31717265 Free PMC article. Review.