Influence of sources of dietary oils on the life span of stroke-prone spontaneously hypertensive rats - PubMed (original) (raw)

Influence of sources of dietary oils on the life span of stroke-prone spontaneously hypertensive rats

W M Ratnayake et al. Lipids. 2000 Apr.

Abstract

In recent studies, the life span of stroke-prone spontaneously hypertensive (SHRSP) rats was altered by a variety of dietary fats. It was relatively shorter in rats fed canola oil as the sole source of fat. The present study was performed to find out whether the fatty acid profile and the high content of sulfur compounds in canola oil could modulate the life span of SHRSP rats. SHRSP rats (47 d old, n = 23/group) were matched by body weight and systolic blood pressure and fed semipurified diets containing 10% canola oil, high-palmitic canola oil, low-sulfur canola oil, soybean oil, high-oleic safflower oil, a fat blend that mimicked the fatty acid composition of canola oil, or a fat blend high in saturated fatty acids. A 1% sodium chloride solution was used as drinking water to induce hypertension. After consuming the diets for 37 d, five rats from each dietary group were killed for collection of blood and tissue samples for biochemical analysis. The 18 remaining animals from each group were used for determining their life span. The mean survival time of SHRSP rats fed canola oil (87.4+/-4.0 d) was not significantly different (P > 0.05) from those fed low-sulfur canola oil (89.7+/-8.5 d), suggesting that content of sulfur in canola oil has no effect on the life span of SHRSP rats. The SHRSP rats fed the noncanola oil-based diets lived longer (mean survival time difference was 6-13 d, P < 0.05) than those fed canola and low-sulfur canola oils. No marked differences in the survival times were observed among the noncanola oil-based groups. The fatty acid composition of the dietary oils and of red blood cells and liver of SHRSP rats killed after 37 d of treatment showed no relationship with the survival times. These results suggest that the fatty acid profile of vegetable oils plays no important role on the life span of SHRSP rat. However, phytosterols in the dietary oils and in liver and brain were inversely correlated with the mean survival times,indicating that the differential effects of vegetable oils might be ascribed, at least partly, to their different phytosterol contents.

PubMed Disclaimer

Similar articles

• Vegetable oils high in phytosterols make erythrocytes less deformable and shorten the life span of stroke-prone spontaneously hypertensive rats.
  Ratnayake WM, L'Abbé MR, Mueller R, Hayward S, Plouffe L, Hollywood R, Trick K. Ratnayake WM, et al. J Nutr. 2000 May;130(5):1166-78. doi: 10.1093/jn/130.5.1166. J Nutr. 2000. PMID: 10801914
• Rapeseed oil ingestion and exacerbation of hypertension-related conditions in stroke prone spontaneously hypertensive rats.
  Naito Y, Nagata T, Takano Y, Nagatsu T, Ohara N. Naito Y, et al. Toxicology. 2003 May 3;187(2-3):205-16. doi: 10.1016/s0300-483x(03)00052-0. Toxicology. 2003. PMID: 12699909
• Phytosterol additives increase blood pressure and promote stroke onset in salt-loaded stroke-prone spontaneously hypertensive rats.
  Ogawa H, Yamamoto K, Kamisako T, Meguro T. Ogawa H, et al. Clin Exp Pharmacol Physiol. 2003 Dec;30(12):919-24. doi: 10.1111/j.1440-1681.2003.03939.x. Clin Exp Pharmacol Physiol. 2003. PMID: 14678230
• Dietary lipids impacts on healthy ageing.
  Okuyama H, Yamada K, Miyazawa D, Yasui Y, Ohara N. Okuyama H, et al. Lipids. 2007 Sep;42(9):821-5. doi: 10.1007/s11745-007-3073-1. Epub 2007 Jun 2. Lipids. 2007. PMID: 17546469 Review.
• Monounsaturated oils do not all have the same effect on plasma cholesterol.
  Truswell AS, Choudhury N. Truswell AS, et al. Eur J Clin Nutr. 1998 May;52(5):312-5. doi: 10.1038/sj.ejcn.1600566. Eur J Clin Nutr. 1998. PMID: 9630379 Review.

Cited by

• Sitosterolemia--a rare disease. Are elevated plant sterols an additional risk factor?
  Sudhop T, von Bergmann K. Sudhop T, et al. Z Kardiol. 2004 Dec;93(12):921-8. doi: 10.1007/s00392-004-0165-2. Z Kardiol. 2004. PMID: 15599566 Review.
• Dietary phytosterols and phytostanols decrease cholesterol levels but increase blood pressure in WKY inbred rats in the absence of salt-loading.
  Chen Q, Gruber H, Swist E, Coville K, Pakenham C, Ratnayake WM, Scoggan KA. Chen Q, et al. Nutr Metab (Lond). 2010 Feb 12;7:11. doi: 10.1186/1743-7075-7-11. Nutr Metab (Lond). 2010. PMID: 20637058 Free PMC article.
• The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats.
  Papazzo A, Conlan X, Lexis L, Lewandowski P. Papazzo A, et al. Lipids Health Dis. 2011 Oct 17;10:180. doi: 10.1186/1476-511X-10-180. Lipids Health Dis. 2011. PMID: 21999921 Free PMC article.
• Comparative health effects of margarines fortified with plant sterols and stanols on a rat model for hemorrhagic stroke.
  Ratnayake WM, Plouffe L, L'Abbé MR, Trick K, Mueller R, Hayward S. Ratnayake WM, et al. Lipids. 2003 Dec;38(12):1237-47. doi: 10.1007/s11745-003-1184-8. Lipids. 2003. PMID: 14870926
• Rapid bioassay-guided screening of toxic substances in vegetable oils that shorten the life of SHRSP rats.
  Ratnayake S, Lewandowski P. Ratnayake S, et al. Lipids Health Dis. 2010 Feb 2;9:13. doi: 10.1186/1476-511X-9-13. Lipids Health Dis. 2010. PMID: 20122175 Free PMC article.

References

1. 1. Biol Pharm Bull. 1996 Apr;19(4):554-7 - PubMed
2. 1. Biochim Biophys Acta. 1989 Sep 25;1005(2):187-91 - PubMed
3. 1. Clin Exp Pharmacol Physiol Suppl. 1992;20:11-6 - PubMed
4. 1. Clin Exp Pharmacol Physiol. 1996 Jun-Jul;23 (6-7):508-13 - PubMed
5. 1. J Hypertens Suppl. 1986 Oct;4(3):S449-52 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Medical

  • MedlinePlus Health Information