Parabrachial lesions disrupt responses of rats to amino acid devoid diets, to protein-free diets, but not to high-protein diets - PubMed (original) (raw)

Parabrachial lesions disrupt responses of rats to amino acid devoid diets, to protein-free diets, but not to high-protein diets

G Fromentin et al. Physiol Behav. 2000 Aug-Sep.

Abstract

Normal rats "reduce" intake of diets that lack an essential amino acid (THR-DEV), are protein free (PO%), or contain a high proportion of protein (P75%). We tested the importance of the parabrachial nuclei (PBN) in signaling such adjustments of food intake by placing electrophysiologically guided lesions in these nuclei at points that responded to gustatory stimuli. When fed the THR-DEV diet, rats with PBN lesions (PBNx) decreased their food intake significantly less than the controls (78.5 vs. 44.4%). When put on a P0% diet, PBNx animals decreased their intake only 8% compared with 23% for our CONT group. When put on a P75% diet, however, both groups decreased their intake in an equivalent amount. These experiments show that the PBN is involved in the learned aversion to an amino acid devoid diet.

PubMed Disclaimer

Cited by

The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal.
Gietzen DW, Aja SM. Gietzen DW, et al. Mol Neurobiol. 2012 Oct;46(2):332-48. doi: 10.1007/s12035-012-8283-8. Epub 2012 Jun 7. Mol Neurobiol. 2012. PMID: 22674217 Free PMC article. Review.

Parabrachial lesions disrupt responses of rats to amino acid devoid diets, to protein-free diets, but not to high-protein diets - PubMed (original) (raw)