Reactive oxygen species in cell signaling - PubMed (original) (raw)
Review
Reactive oxygen species in cell signaling
V J Thannickal et al. Am J Physiol Lung Cell Mol Physiol. 2000 Dec.
Free article
Abstract
Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant capacity, damage to cellular macromolecules such as lipids, protein, and DNA may ensue. Such a state of "oxidative stress" is thought to contribute to the pathogenesis of a number of human diseases including those of the lung. Recent studies have also implicated ROS that are generated by specialized plasma membrane oxidases in normal physiological signaling by growth factors and cytokines. In this review, we examine the evidence for ligand-induced generation of ROS, its cellular sources, and the signaling pathways that are activated. Emerging concepts on the mechanisms of signal transduction by ROS that involve alterations in cellular redox state and oxidative modifications of proteins are also discussed.
Similar articles
- Reactive oxygen species in health and disease.
Datta K, Sinha S, Chattopadhyay P. Datta K, et al. Natl Med J India. 2000 Nov-Dec;13(6):304-10. Natl Med J India. 2000. PMID: 11209486 Review. - Signaling by reactive oxygen species in the nervous system.
Maher P, Schubert D. Maher P, et al. Cell Mol Life Sci. 2000 Aug;57(8-9):1287-305. doi: 10.1007/pl00000766. Cell Mol Life Sci. 2000. PMID: 11028919 Free PMC article. Review. - Reactive oxygen species, inflammation, and lung diseases.
Rosanna DP, Salvatore C. Rosanna DP, et al. Curr Pharm Des. 2012;18(26):3889-900. doi: 10.2174/138161212802083716. Curr Pharm Des. 2012. PMID: 22632750 Review. - [Reactive Oxygen Species (ROS) Signaling: Regulatory Mechanisms and Pathophysiological Roles].
Hirata Y. Hirata Y. Yakugaku Zasshi. 2019;139(10):1235-1241. doi: 10.1248/yakushi.19-00141. Yakugaku Zasshi. 2019. PMID: 31582606 Review. Japanese. - Reactive oxygen species and mitochondria: A nexus of cellular homeostasis.
Dan Dunn J, Alvarez LA, Zhang X, Soldati T. Dan Dunn J, et al. Redox Biol. 2015 Dec;6:472-485. doi: 10.1016/j.redox.2015.09.005. Epub 2015 Sep 10. Redox Biol. 2015. PMID: 26432659 Free PMC article. Review.
Cited by
- The Role of MicroRNAs in Vitiligo: Regulators and Therapeutic Targets.
Li L. Li L. Ann Dermatol. 2020 Dec;32(6):441-451. doi: 10.5021/ad.2020.32.6.441. Epub 2020 Nov 11. Ann Dermatol. 2020. PMID: 33911786 Free PMC article. Review. - Eltrombopag modulates reactive oxygen species and decreases acute myeloid leukemia cell survival.
Kalota A, Selak MA, Garcia-Cid LA, Carroll M. Kalota A, et al. PLoS One. 2015 Apr 27;10(4):e0126691. doi: 10.1371/journal.pone.0126691. eCollection 2015. PLoS One. 2015. PMID: 25915523 Free PMC article. - Phytochemical andrographolide modulates NF-κB and JNK in human neuroblastoma SH-SY5Y cells, a cell model for Parkinson's disease.
Ketterman AJ, Wongtrakul J, Saisawang C. Ketterman AJ, et al. Heliyon. 2020 Jun 9;6(6):e04121. doi: 10.1016/j.heliyon.2020.e04121. eCollection 2020 Jun. Heliyon. 2020. PMID: 32551381 Free PMC article. - Inflammation and oxidative stress in angiogenesis and vascular disease.
Kim YW, West XZ, Byzova TV. Kim YW, et al. J Mol Med (Berl). 2013 Mar;91(3):323-8. doi: 10.1007/s00109-013-1007-3. Epub 2013 Feb 22. J Mol Med (Berl). 2013. PMID: 23430240 Free PMC article. Review. - Protective effects of andrographolide analogue AL-1 on ROS-induced RIN-mβ cell death by inducing ROS generation.
Yan GR, Zhou HH, Wang Y, Zhong Y, Tan ZL, Wang Y, He QY. Yan GR, et al. PLoS One. 2013 Jun 4;8(6):e63656. doi: 10.1371/journal.pone.0063656. Print 2013. PLoS One. 2013. PMID: 23750203 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources