Vitamin A, infection, and immune function - PubMed (original) (raw)
Review
Vitamin A, infection, and immune function
C B Stephensen. Annu Rev Nutr. 2001.
Abstract
In populations where vitamin A availability from food is low, infectious diseases can precipitate vitamin A deficiency by decreasing intake, decreasing absorption, and increasing excretion. Infectious diseases that induce the acute-phase response also impair the assessment of vitamin A status by transiently depressing serum retinol concentrations. Vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of neutrophils, macrophages, and natural killer cells. Vitamin A is also required for adaptive immunity and plays a role in the development of T both-helper (Th) cells and B-cells. In particular, vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished. These changes in mucosal epithelial regeneration and immune function presumably account for the increased mortality seen in vitamin A-deficient infants, young children, and pregnant women in many areas of the world today.
Similar articles
- The pleiotropic role of vitamin A in regulating mucosal immunity.
Sirisinha S. Sirisinha S. Asian Pac J Allergy Immunol. 2015 Jun;33(2):71-89. Asian Pac J Allergy Immunol. 2015. PMID: 26141028 Review. - Vitamin A as an immunomodulating agent.
Rumore MM. Rumore MM. Clin Pharm. 1993 Jul;12(7):506-14. Clin Pharm. 1993. PMID: 8354037 Review. - Vitamin A as an anti-inflammatory agent.
Reifen R. Reifen R. Proc Nutr Soc. 2002 Aug;61(3):397-400. doi: 10.1079/PNS2002172. Proc Nutr Soc. 2002. PMID: 12230799 Review. - Effects of vitamin A deficiency on mucosal immunity and response to intestinal infection in rats.
Yang Y, Yuan Y, Tao Y, Wang W. Yang Y, et al. Nutrition. 2011 Feb;27(2):227-32. doi: 10.1016/j.nut.2009.11.024. Epub 2010 Apr 3. Nutrition. 2011. PMID: 20363594 - [Advances on studies related to the requirement of vitamin A for infants, young and preschool children].
Yu Y, Zhao Y, Pan L, Yin S. Yu Y, et al. Wei Sheng Yan Jiu. 2012 Jan;41(1):132-6. Wei Sheng Yan Jiu. 2012. PMID: 22443072 Review. Chinese.
Cited by
- Assessment of Supplementation with Different Biomolecules in the Prevention and Treatment of COVID-19.
González-Acedo A, Manzano-Moreno FJ, García-Recio E, Ruiz C, Luna-Bertos E, Costela-Ruiz VJ. González-Acedo A, et al. Nutrients. 2024 Sep 11;16(18):3070. doi: 10.3390/nu16183070. Nutrients. 2024. PMID: 39339670 Free PMC article. Review. - The association between serum vitamin A concentrations and virus hepatitis among U.S. adults from the NHANES database: a cross-sectional study.
Liu M, Fu J, Zhang X, Fu Q, Ji Y, Chen S. Liu M, et al. Front Nutr. 2024 Aug 1;11:1387461. doi: 10.3389/fnut.2024.1387461. eCollection 2024. Front Nutr. 2024. PMID: 39149555 Free PMC article. - Dietary patterns and micronutrients in respiratory infections including COVID-19: a narrative review.
Salehi Z, Askari M, Jafari A, Ghosn B, Surkan PJ, Hosseinzadeh-Attar MJ, Pouraram H, Azadbakht L. Salehi Z, et al. BMC Public Health. 2024 Jun 21;24(1):1661. doi: 10.1186/s12889-024-18760-y. BMC Public Health. 2024. PMID: 38907196 Free PMC article. Review. - Coccidiosis in Egg-Laying Hens and Potential Nutritional Strategies to Modulate Performance, Gut Health, and Immune Response.
Sharma MK, Kim WK. Sharma MK, et al. Animals (Basel). 2024 Mar 27;14(7):1015. doi: 10.3390/ani14071015. Animals (Basel). 2024. PMID: 38612254 Free PMC article. Review. - Pet Wellness and Vitamin A: A Narrative Overview.
Shastak Y, Pelletier W. Shastak Y, et al. Animals (Basel). 2024 Mar 25;14(7):1000. doi: 10.3390/ani14071000. Animals (Basel). 2024. PMID: 38612239 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical