The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines - PubMed (original) (raw)
. 2001 Apr-Jun;12(2):290-6.
Affiliations
- PMID: 11399518
Free article
The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines
V Barak et al. Eur Cytokine Netw. 2001 Apr-Jun.
Free article
Abstract
Sambucus nigra L. products - Sambucol - are based on a standardized black elderberry extract. They are natural remedies with antiviral properties, especially against different strains of influenza virus. Sambucol was shown to be effective in vitro against 10 strains of influenza virus. In a double-blind, placebo-controlled, randomized study, Sambucol reduced the duration of flu symptoms to 3-4 days. Convalescent phase serum showed a higher antibody level to influenza virus in the Sambucol group, than in the control group. The present study aimed to assess the effect of Sambucol products on the healthy immune system - namely, its effect on cytokine production. The production of inflammatory cytokines was tested using blood - derived monocytes from 12 healthy human donors. Adherent monocytes were separated from PBL and incubated with different Sambucol preparations i.e., Sambucol Elderberry Extract, Sambucol Black Elderberry Syrup, Sambucol Immune System and Sambucol for Kids. Production of inflammatory cytokines (IL-1 beta, TNF-alpha, IL-6, IL-8) was significantly increased, mostly by the Sambucol Black Elderberry Extract (2-45 fold), as compared to LPS, a known monocyte activator (3.6-10.7 fold). The most striking increase was noted in TNF-alpha production (44.9 fold). We conclude from this study that, in addition to its antiviral properties, Sambucol Elderberry Extract and its formulations activate the healthy immune system by increasing inflammatory cytokine production. Sambucol might therefore be beneficial to the immune system activation and in the inflammatory process in healthy individuals or in patients with various diseases. Sambucol could also have an immunoprotective or immunostimulatory effect when administered to cancer or AIDS patients, in conjunction with chemotherapeutic or other treatments. In view of the increasing popularity of botanical supplements, such studies and investigations in vitro, in vivo and in clinical trials need to be developed.
Similar articles
- The effect of herbal remedies on the production of human inflammatory and anti-inflammatory cytokines.
Barak V, Birkenfeld S, Halperin T, Kalickman I. Barak V, et al. Isr Med Assoc J. 2002 Nov;4(11 Suppl):919-22. Isr Med Assoc J. 2002. PMID: 12455180 - PADMA-28, a Tibetan herbal preparation is an inhibitor of inflammatory cytokine production.
Barak V, Kalickman I, Halperin T, Birkenfeld S, Ginsburg I. Barak V, et al. Eur Cytokine Netw. 2004 Jul-Sep;15(3):203-9. Eur Cytokine Netw. 2004. PMID: 15542444 - Augmented TNF-alpha and IL-10 production by primed human monocytes following interaction with oxidatively modified autologous erythrocytes.
Liese AM, Siddiqi MQ, Siegel JH, Denny T, Spolarics Z. Liese AM, et al. J Leukoc Biol. 2001 Aug;70(2):289-96. J Leukoc Biol. 2001. PMID: 11493622 - Systemic inflammatory response to exhaustive exercise. Cytokine kinetics.
Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K. Suzuki K, et al. Exerc Immunol Rev. 2002;8:6-48. Exerc Immunol Rev. 2002. PMID: 12690937 Review. - The role of cytokines in osteoarthritis pathophysiology.
Fernandes JC, Martel-Pelletier J, Pelletier JP. Fernandes JC, et al. Biorheology. 2002;39(1-2):237-46. Biorheology. 2002. PMID: 12082286 Review.
Cited by
- Natural Product-Derived Phytochemicals for Influenza A Virus (H1N1) Prevention and Treatment.
Li R, Han Q, Li X, Liu X, Jiao W. Li R, et al. Molecules. 2024 May 17;29(10):2371. doi: 10.3390/molecules29102371. Molecules. 2024. PMID: 38792236 Free PMC article. Review. - Sambucus nigra L. (fam. Viburnaceae) in Sicily: Distribution, Ecology, Traditional Use and Therapeutic Properties.
Sala G, Pasta S, Maggio A, La Mantia T. Sala G, et al. Plants (Basel). 2023 Sep 30;12(19):3457. doi: 10.3390/plants12193457. Plants (Basel). 2023. PMID: 37836198 Free PMC article. - Elderberry diet improves gut-brain axis dysfunction, neuroinflammation, and cognitive impairment in the rat model of irritable bowel syndrome.
Namakin K, Moghaddam MH, Sadeghzadeh S, Mehranpour M, Vakili K, Fathi M, Golshan A, Bayat AH, Tajik AH, Eskandari N, Mohammadzadeh I, Benisi SZ, Aliaghaei A, Abdollahifar MA. Namakin K, et al. Metab Brain Dis. 2023 Jun;38(5):1555-1572. doi: 10.1007/s11011-023-01187-6. Epub 2023 Mar 6. Metab Brain Dis. 2023. PMID: 36877342 - Assessment of the role of anthocyanin standardized elderberry (Sambucus nigra) extract as an immune-stimulating nutraceutical of Nile tilapia, Oreochromis niloticus.
Khan MM, Mortuza A, Ibrahim M, Mustafa A. Khan MM, et al. PLoS One. 2022 Dec 30;17(12):e0279471. doi: 10.1371/journal.pone.0279471. eCollection 2022. PLoS One. 2022. PMID: 36584192 Free PMC article. - The Pros and Cons of Using Elderberry (Sambucus nigra) for Prevention and Treatment of COVID-19.
Asgary S, Pouramini A. Asgary S, et al. Adv Biomed Res. 2022 Oct 31;11:96. doi: 10.4103/abr.abr_146_21. eCollection 2022. Adv Biomed Res. 2022. PMID: 36518861 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources