Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses - PubMed (original) (raw)
. 2001 Sep 7;293(5536):1840-2.
doi: 10.1126/science.1062882.
Affiliations
- PMID: 11546875
- DOI: 10.1126/science.1062882
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
M Hatta et al. Science. 2001.
Abstract
In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.
Comment in
- Virology. A molecular whodunit.
Webster RG. Webster RG. Science. 2001 Sep 7;293(5536):1773-5. doi: 10.1126/science.1065206. Science. 2001. PMID: 11546856 No abstract available.
Similar articles
- The genesis of a pandemic influenza virus.
Russell CJ, Webster RG. Russell CJ, et al. Cell. 2005 Nov 4;123(3):368-71. doi: 10.1016/j.cell.2005.10.019. Cell. 2005. PMID: 16269328 - PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice.
Shinya K, Hamm S, Hatta M, Ito H, Ito T, Kawaoka Y. Shinya K, et al. Virology. 2004 Mar 15;320(2):258-66. doi: 10.1016/j.virol.2003.11.030. Virology. 2004. PMID: 15016548 - Reverse genetics approach towards understanding pathogenesis of H5N1 Hong Kong influenza A virus infection.
Hatta M, Neumann G, Kawaoka Y. Hatta M, et al. Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1841-3. doi: 10.1098/rstb.2001.1000. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11779382 Free PMC article. Review. - Virology. Clues to the virulence of H5N1 viruses in humans.
Krug RM. Krug RM. Science. 2006 Mar 17;311(5767):1562-3. doi: 10.1126/science.1125998. Science. 2006. PMID: 16543447 No abstract available. - [Influenza A(H5N1) in Hong Kong: forerunner of a pandemic or an only scientifically interesting phenomenon and a useful exercise in pandemiology?].
de Jong JC, Claas EC, Osterhaus AD. de Jong JC, et al. Tijdschr Diergeneeskd. 1998 May 1;123(9):278-82. Tijdschr Diergeneeskd. 1998. PMID: 9602508 Review. Dutch.
Cited by
- Genetic characteristics and pathogenesis of H5 low pathogenic avian influenza viruses from wild birds and domestic ducks in South Korea.
Lee YN, Lee DH, Cheon SH, Park YR, Baek YG, Si YJ, Kye SJ, Lee EK, Heo GB, Bae YC, Lee MH, Lee YJ. Lee YN, et al. Sci Rep. 2020 Jul 22;10(1):12151. doi: 10.1038/s41598-020-68720-w. Sci Rep. 2020. PMID: 32699272 Free PMC article. - A comparative study of human TLR 7/8 stimulatory trimer compositions in influenza A viral genomes.
Yang CW, Chen SM. Yang CW, et al. PLoS One. 2012;7(2):e30751. doi: 10.1371/journal.pone.0030751. Epub 2012 Feb 17. PLoS One. 2012. PMID: 22363482 Free PMC article. - Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018.
Saeed NM, Rashid PMA, Dyary HO. Saeed NM, et al. BMC Vet Res. 2021 Mar 19;17(1):124. doi: 10.1186/s12917-021-02831-y. BMC Vet Res. 2021. PMID: 33740981 Free PMC article. - A molecular trigger for intercontinental epidemics of group A Streptococcus.
Zhu L, Olsen RJ, Nasser W, Beres SB, Vuopio J, Kristinsson KG, Gottfredsson M, Porter AR, DeLeo FR, Musser JM. Zhu L, et al. J Clin Invest. 2015 Sep;125(9):3545-59. doi: 10.1172/JCI82478. Epub 2015 Aug 10. J Clin Invest. 2015. PMID: 26258415 Free PMC article. - Host range restriction and pathogenicity in the context of influenza pandemic.
Neumann G, Kawaoka Y. Neumann G, et al. Emerg Infect Dis. 2006 Jun;12(6):881-6. doi: 10.3201/eid1206.051336. Emerg Infect Dis. 2006. PMID: 16707041 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical