Larry Clark's legacy: randomized controlled, selenium-based prostate cancer chemoprevention trials - PubMed (original) (raw)
Review
Larry Clark's legacy: randomized controlled, selenium-based prostate cancer chemoprevention trials
J R Marshall. Nutr Cancer. 2001.
Abstract
Several important clinical trials under way at the Arizona Cancer Center seek to build on the results of Clark's 1996 study of selenium and decreased risk of prostate cancer. Those results, an unanticipated end point of a clinical trial, suggest that selenium has significant preventive power. The studies under way involve continued follow-up of the study cohort that generated the 1996 results and trials of selenium among men with negative biopsies, men with high-grade prostatic intraepithelial neoplasia, men with prostate cancer treated with selenium before prostatectomy, and men with prostate cancer who have chosen watchful waiting rather than active intervention. These studies promise important opportunities to validate Clark's original results.
Similar articles
- Review of vitamin E and selenium in the prevention of prostate cancer: implications of the selenium and vitamin E chemoprevention trial.
Pak RW, Lanteri VJ, Scheuch JR, Sawczuk IS. Pak RW, et al. Integr Cancer Ther. 2002 Dec;1(4):338-44. doi: 10.1177/1534735402238186. Integr Cancer Ther. 2002. PMID: 14664728 Review. - Design and progress of a trial of selenium to prevent prostate cancer among men with high-grade prostatic intraepithelial neoplasia.
Marshall JR, Sakr W, Wood D, Berry D, Tangen C, Parker F, Thompson I, Lippman SM, Lieberman R, Alberts D, Jarrard D, Coltman C, Greenwald P, Minasian L, Crawford ED. Marshall JR, et al. Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1479-84. doi: 10.1158/1055-9965.EPI-05-0585. Cancer Epidemiol Biomarkers Prev. 2006. PMID: 16896036 Clinical Trial. - Chemoprevention of prostate cancer: agents and study designs.
Thompson IM. Thompson IM. J Urol. 2007 Sep;178(3 Pt 2):S9-S13. doi: 10.1016/j.juro.2007.03.138. Epub 2007 Jul 20. J Urol. 2007. PMID: 17644117 Review. - A randomized double-blind placebo controlled phase I-II study on clinical and molecular effects of dietary supplements in men with precancerous prostatic lesions. Chemoprevention or "chemopromotion"?
Gontero P, Marra G, Soria F, Oderda M, Zitella A, Baratta F, Chiorino G, Gregnanin I, Daniele L, Cattel L, Frea B, Brusa P. Gontero P, et al. Prostate. 2015 Aug 1;75(11):1177-86. doi: 10.1002/pros.22999. Epub 2015 Apr 20. Prostate. 2015. PMID: 25893930 Clinical Trial.
Cited by
- Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention.
Yildiz A, Kaya Y, Tanriverdi O. Yildiz A, et al. J Cancer Prev. 2019 Sep;24(3):146-154. doi: 10.15430/JCP.2019.24.3.146. Epub 2019 Sep 30. J Cancer Prev. 2019. PMID: 31624720 Free PMC article. Review. - Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications.
Chhabra G, Singh CK, Ndiaye MA, Fedorowicz S, Molot A, Ahmad N. Chhabra G, et al. Cancer Lett. 2018 May 28;422:9-18. doi: 10.1016/j.canlet.2018.02.025. Epub 2018 Feb 20. Cancer Lett. 2018. PMID: 29471004 Free PMC article. Review. - Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate β-lyase activity and can transaminate L-selenomethionine.
Pinto JT, Krasnikov BF, Alcutt S, Jones ME, Dorai T, Villar MT, Artigues A, Li J, Cooper AJ. Pinto JT, et al. J Biol Chem. 2014 Nov 7;289(45):30950-61. doi: 10.1074/jbc.M114.591461. Epub 2014 Sep 17. J Biol Chem. 2014. PMID: 25231977 Free PMC article. - Selenium for preventing cancer.
Vinceti M, Dennert G, Crespi CM, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Del Giovane C. Vinceti M, et al. Cochrane Database Syst Rev. 2014 Mar 30;2014(3):CD005195. doi: 10.1002/14651858.CD005195.pub3. Cochrane Database Syst Rev. 2014. PMID: 24683040 Free PMC article. Updated. Review. - Lycopene for the prevention of prostate cancer.
Ilic D, Forbes KM, Hassed C. Ilic D, et al. Cochrane Database Syst Rev. 2011 Nov 9;2011(11):CD008007. doi: 10.1002/14651858.CD008007.pub2. Cochrane Database Syst Rev. 2011. PMID: 22071840 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical