Microsatellite characterization of Plasmodium falciparum from cerebral and uncomplicated malaria patients in southern Vietnam - PubMed (original) (raw)

Microsatellite characterization of Plasmodium falciparum from cerebral and uncomplicated malaria patients in southern Vietnam

Marcelo U Ferreira et al. J Clin Microbiol. 2002 May.

Abstract

If parasite genotype influences the clinical course of malaria, we expect that isolates from patients with similar pathology would be more closely related than would be expected by chance. To explore this prediction, we typed nine microsatellite markers in sympatric Plasmodium falciparum isolates from cerebral and uncomplicated malaria patients from Vietnam. Temporal structure and linkage disequilibrium were also examined in this data set.

PubMed Disclaimer

Figures

FIG. 1.

FIG. 1.

Neighbor-joining tree showing the relationships between microsatellite haplotypes of 101 P. falciparum isolates from southern Vietnam. The predominant allele at each locus was used to define nine-locus parasite haplotypes in multiple-clone infections. Dates of collection of isolates are indicated as follows: double underlining (n = 22), January to April 1996; italics (n = 37), May to July 1996; single underlining (n = 8), August to October 1996; and normal type (n = 34), November 1996 to January 1997. Terminal branches of zero length mark identical haplotypes. Isolates from cerebral malaria patients (n = 8) are boxed.

References

    1. Al-Yaman, F., B. Genton, J. C. Reeder, D. Mokela, R. F. Anders, and M. P. Alpers. 1997. Humoral response to defined Plasmodium falciparum antigens in cerebral and uncomplicated malaria and their relationship to parasite genotype. Am. J. Trop. Med. Hyg. 56**:**430-435. -PubMed
    1. Anderson, T. J. C., B. Haubold, J. T. Williams, J. G. Estrada-Franco, L. Richardson, R. Mollinedo, M. Bockarie, J. Mokili, S. Mharakurwa, N. French, J. Whitworth, I. D. Velez, A. H. Brockman, F. Nosten, M. U. Ferreira, and K. P. Day. 2000. Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Mol. Biol. Evol. 17**:**1467-1482. -PubMed
    1. Anderson, T. J. C., X. Z. Su, M. Bockerie, M. Lagog, and K. P. Day. 1999. Twelve microsatellite markers for characterization of Plasmodium falciparum from finger-prick blood samples. Parasitology 119**:**113-126. -PubMed
    1. Ariey, F., D. Hommel, C. Le Scanf, J. B. Duichemin, C. Peneau, A. Hulin, J. L. Sarthou, J. M. Reynes, T. Fandeur, and O. Mercereau-Puijalon. 2001. Association of severe malaria with a specific Plasmodium falciparum genotype in French Guyana. J. Infect. Dis. 184**:**237-241. -PubMed
    1. Bull, P. C., M. Kortok, O. Kai, F. Ndungu, A. Ross, B. S. Lowe, C. I. Newbold, and K. Marsh. 2000. _Plasmodium falciparum_-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age. J. Infect. Dis. 182**:**252-259. -PubMed

Publication types

MeSH terms

LinkOut - more resources