Assessing meaningful change in quality of life over time: a users' guide for clinicians - PubMed (original) (raw)
Review
Assessing meaningful change in quality of life over time: a users' guide for clinicians
Mirjam A G Sprangers et al. Mayo Clin Proc. 2002 Jun.
Abstract
The objective of this article is to help clinicians interpret trial-based quality of life (QOL) changes over time. We address a series of questions and provide guidelines that are fundamental to assessing and interpreting change. The issues addressed are as follows: (1) What are the characteristics of the population for whom changes in QOL are reported? (2) Is the QOL questionnaire reliable, valid, and responsive to change? (3) Are the timing and frequency of assessments adequate? (4) Is the study adequately powered? (5) How are multiple QOL outcomes addressed in analyses? (6) How are multiple time points handled? (7) Can alternative explanations account for the observed change or lack of observed change (eg, handling of missing data, survival differences, and changes in patient's QOL perspective over time)? and (8) How is statistical significance translated into meaningful change? These guidelines will support clinicians in reviewing the clinical trial literature, which in turn can help them use the data in the treatment decision process.
Similar articles
- The clinical significance of quality-of-life results: practical considerations for specific audiences.
Symonds T, Berzon R, Marquis P, Rummans TA; Clinical Significance Consensus Meeting Group. Symonds T, et al. Mayo Clin Proc. 2002 Jun;77(6):572-83. doi: 10.4065/77.6.572. Mayo Clin Proc. 2002. PMID: 12059128 Review. - Cost-effective models for flutamide for prostate carcinoma patients: are they helpful to policy makers?
Bennett CL, Matchar D, McCrory D, McLeod DG, Crawford ED, Hillner BE. Bennett CL, et al. Cancer. 1996 May 1;77(9):1854-61. doi: 10.1002/(SICI)1097-0142(19960501)77:9<1854::AID-CNCR15>3.0.CO;2-Z. Cancer. 1996. PMID: 8646685 - First-line treatment of metastatic prostate cancer. Androgen suppression for symptomatic disease.
[No authors listed] [No authors listed] Prescrire Int. 2013 Feb;22(135):48-51. Prescrire Int. 2013. PMID: 23444510 Review. - Health-related quality of life in early breast cancer.
Groenvold M. Groenvold M. Dan Med Bull. 2010 Sep;57(9):B4184. Dan Med Bull. 2010. PMID: 20816024 - Quality of life in oncology trials: a clinical guide.
Movsas B. Movsas B. Semin Radiat Oncol. 2003 Jul;13(3):235-47. doi: 10.1016/S1053-4296(03)00029-8. Semin Radiat Oncol. 2003. PMID: 12903013 Review.
Cited by
- Electro-acupuncture for health-related quality of life and symptoms in patients with gastric cancer undergoing adjuvant chemotherapy (EAGER): a protocol for a multicenter randomized controlled trial.
Chang X, Zhu Y, Zhao W, Liu Y, He Y, Chen Y, Xu D, Mao JJ, Zhang HB. Chang X, et al. Health Qual Life Outcomes. 2023 Jul 11;21(1):70. doi: 10.1186/s12955-023-02135-9. Health Qual Life Outcomes. 2023. PMID: 37434165 Free PMC article. - Establishing Minimal Clinically Important Differences for the Quality of Life Instrument in Patients With Breast Cancer QLICP-BR (V2.0) Based on Anchor-Based and Distribution-Based Methods.
Li F, Liu Y, Wan C, Zhou J, Tan J, Chen H. Li F, et al. Front Oncol. 2022 May 2;12:753729. doi: 10.3389/fonc.2022.753729. eCollection 2022. Front Oncol. 2022. PMID: 35586490 Free PMC article. - Health-related quality of life in cancer patients treated with immune checkpoint inhibitors: A systematic review on reporting of methods in randomized controlled trials.
Faury S, Foucaud J. Faury S, et al. PLoS One. 2020 Jan 24;15(1):e0227344. doi: 10.1371/journal.pone.0227344. eCollection 2020. PLoS One. 2020. PMID: 31978145 Free PMC article. - International multiphase mixed methods study protocol to develop a patient-reported outcome instrument for children and adolescents with lower limb deformities.
Chhina H, Klassen A, Kopec JA, Oliffe J, Cooper A. Chhina H, et al. BMJ Open. 2019 May 5;9(5):e027079. doi: 10.1136/bmjopen-2018-027079. BMJ Open. 2019. PMID: 31061048 Free PMC article. - When global rating of change contradicts observed change: Examining appraisal processes underlying paradoxical responses over time.
Schwartz CE, Powell VE, Rapkin BD. Schwartz CE, et al. Qual Life Res. 2017 Apr;26(4):847-857. doi: 10.1007/s11136-016-1414-3. Epub 2016 Oct 8. Qual Life Res. 2017. PMID: 27722830
Publication types
MeSH terms
Substances
Grants and funding
- CA15083/CA/NCI NIH HHS/United States
- CA25224/CA/NCI NIH HHS/United States
- CA35101/CA/NCI NIH HHS/United States
- CA35103/CA/NCI NIH HHS/United States
- CA35113/CA/NCI NIH HHS/United States
- CA35195/CA/NCI NIH HHS/United States
- CA35269/CA/NCI NIH HHS/United States
- CA35272/CA/NCI NIH HHS/United States
- CA35415/CA/NCI NIH HHS/United States
- CA35448/CA/NCI NIH HHS/United States
- CA37404/CA/NCI NIH HHS/United States
- CA37417/CA/NCI NIH HHS/United States
- CA52352/CA/NCI NIH HHS/United States
- CA63849/CA/NCI NIH HHS/United States
LinkOut - more resources
Full Text Sources