On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine - PubMed (original) (raw)
On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine
D C Roberts et al. Pharmacol Biochem Behav. 1977 Jun.
Abstract
The role of ascending noradrenergic (NA) and dopaminergic (DA) systems in intravenous self-administration of cocaine in rats was investigated by examining the effects of 6-hydroxydopamine-induced lesions of these systems on responding for the drug on a FR-1 schedule of reinforcement. Lesions of the dorsal and ventral NA bundles that reduced hippocampal-cortical NA by 96% and hypothalamic NA by 72% failed to have any effects on responding for cocaine. Lesions of the nucleus accumbens that reduced the DA content of this nucleus by 90% resulted in a significant and long-lasting (15 days) reduction in self-administration of cocaine. Apomorphine self-administration was not affected in the same animals. Identical lesions of the n accumbens had only transient (2-3 days) effects on food-reinforced operant responding, suggesting that the prolonged disruption of cocaine self-administration was not the result of motor deficits. The results are discussed with reference to the possibility that DA terminals in the n accumbens may mediate some of the positive reinforcing properties of cocaine.
Similar articles
- Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats.
Roberts DC, Koob GF. Roberts DC, et al. Pharmacol Biochem Behav. 1982 Nov;17(5):901-4. doi: 10.1016/0091-3057(82)90469-5. Pharmacol Biochem Behav. 1982. PMID: 6817350 - Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats.
Pettit HO, Ettenberg A, Bloom FE, Koob GF. Pettit HO, et al. Psychopharmacology (Berl). 1984;84(2):167-73. doi: 10.1007/BF00427441. Psychopharmacology (Berl). 1984. PMID: 6438676 - Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems.
Robbins TW, Everitt BJ. Robbins TW, et al. Neuropharmacology. 1987 Jul;26(7B):893-901. doi: 10.1016/0028-3908(87)90067-0. Neuropharmacology. 1987. PMID: 3116447 Review. - Neural systems underlying arousal and attention. Implications for drug abuse.
Robbins TW, Granon S, Muir JL, Durantou F, Harrison A, Everitt BJ. Robbins TW, et al. Ann N Y Acad Sci. 1998 Jun 21;846:222-37. Ann N Y Acad Sci. 1998. PMID: 9668410 Review.
Cited by
- Satiating effects of cocaine are controlled by dopamine actions in the nucleus accumbens core.
Suto N, Wise RA. Suto N, et al. J Neurosci. 2011 Dec 7;31(49):17917-22. doi: 10.1523/JNEUROSCI.1903-11.2011. J Neurosci. 2011. PMID: 22159106 Free PMC article. - The effect of haloperidol on cocaine self-administration is augmented with repeated administrations.
Roberts DC, Vickers G. Roberts DC, et al. Psychopharmacology (Berl). 1987;93(4):526-8. doi: 10.1007/BF00207247. Psychopharmacology (Berl). 1987. PMID: 3124187 - Impact of atypical antipsychotics on quality of life in patients with schizophrenia.
Awad AG, Voruganti LN. Awad AG, et al. CNS Drugs. 2004;18(13):877-93. doi: 10.2165/00023210-200418130-00004. CNS Drugs. 2004. PMID: 15521791 Review. - Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.
Morón JA, Brockington A, Wise RA, Rocha BA, Hope BT. Morón JA, et al. J Neurosci. 2002 Jan 15;22(2):389-95. doi: 10.1523/JNEUROSCI.22-02-00389.2002. J Neurosci. 2002. PMID: 11784783 Free PMC article. - Norepinephrine and stimulant addiction.
Sofuoglu M, Sewell RA. Sofuoglu M, et al. Addict Biol. 2009 Apr;14(2):119-29. doi: 10.1111/j.1369-1600.2008.00138.x. Epub 2008 Sep 22. Addict Biol. 2009. PMID: 18811678 Free PMC article. Review.