Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial - PubMed (original) (raw)
Clinical Trial
. 2002 Nov 9;360(9344):1455-61.
doi: 10.1016/S0140-6736(02)11472-3.
Affiliations
- PMID: 12433513
- DOI: 10.1016/S0140-6736(02)11472-3
Clinical Trial
Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial
Ram B Singh et al. Lancet. 2002.
Expression of concern in
- Expression of concern: Indo-Mediterranean Diet Heart Study.
Horton R. Horton R. Lancet. 2005 Jul 30-Aug 5;366(9483):354-6. doi: 10.1016/S0140-6736(05)67006-7. Lancet. 2005. PMID: 16054927 No abstract available.
Abstract
Background: The rapid emergence of coronary artery disease (CAD) in south Asian people is not explained by conventional risk factors. In view of cardioprotective effects of a Mediterranean style diet rich in alpha-linolenic acid, we assessed the benefits of this diet for patients at high risk of CAD.
Methods: We did a randomised, single-blind trial in 1000 patients with angina pectoris, myocardial infarction, or surrogate risk factors for CAD. 499 patients were allocated to a diet rich in whole grains, fruits, vegetables, walnuts, and almonds. 501 controls consumed a local diet similar to the step I National Cholesterol Education Program (NCEP) prudent diet.
Findings: The intervention group consumed more fruits, vegetables, legumes, walnuts, and almonds than did controls (573 g [SD 127] vs 231 g [19] per day p<0.001). The intervention group had an increased intake of whole grains and mustard or soy bean oil. The mean intake of alpha-linolenic acid was two-fold greater in the intervention group (1.8 g [SD 0.4] vs 0.8 g [0.2] per day, p<0.001). Total cardiac end points were significantly fewer in the intervention group than the controls (39 vs 76 events, p<0.001). Sudden cardiac deaths were also reduced (6 vs 16, p=0.015), as were non-fatal myocardial infarctions (21 vs 43, p<0.001). We noted a significant reduction in serum cholesterol concentration and other risk factors in both groups, but especially in the intervention diet group. In the treatment group, patients with pre-existing CAD had significantly greater benefits compared with such patients in the control group.
Interpretation: An Indo-Mediterranean diet that is rich in alpha-linolenic acid might be more effective in primary and secondary prevention of CAD than the conventional step I NCEP prudent diet.
Comment in
- An Indo-Mediterranean diet was more effective than a control diet in primary and secondary coronary artery disease prevention.
Jain M, Rosenberg M. Jain M, et al. ACP J Club. 2003 May-Jun;138(3):63. ACP J Club. 2003. PMID: 12725618 No abstract available. - An Indo Mediterranean diet was more effective than a conventional prudent diet in reducing coronary artery disease risk factors and events.
Chair SY. Chair SY. Evid Based Nurs. 2003 Jul;6(3):79. doi: 10.1136/ebn.6.3.79. Evid Based Nurs. 2003. PMID: 12882192 No abstract available. - The Indo-Mediterranean diet revisited.
Mann J. Mann J. Lancet. 2005 Jul 30-Aug 5;366(9483):353-4. doi: 10.1016/S0140-6736(05)67005-5. Lancet. 2005. PMID: 16054926 No abstract available. - Indo-Mediterranean diet and progression of coronary artery disease.
Soman CR. Soman CR. Lancet. 2005 Jul 30-Aug 5;366(9483):365-6; author reply 366-7. doi: 10.1016/S0140-6736(05)67014-6. Lancet. 2005. PMID: 16054929 No abstract available.
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