Location, location, location - PubMed (original) (raw)
Location, location, location
Paul A Insel. Trends Endocrinol Metab. 2003 Apr.
Abstract
Increasing evidence documents the co-localization of molecules involved in both the activation and de-activation (desensitization) of signal transduction, especially in G protein-coupled receptor and heterotrimeric G protein-mediated signalling. Of particular note are the recent findings regarding recruitment of cyclic nucleotide phosphodiesterase to beta-arrestin in transfected HEK293 cells and in native cardiac myocytes. Co-localization of G protein pathway signalling molecules probably contribute to both spatial and temporal regulation of signal transduction.