alpha2-Adrenoceptor agonists: shedding light on neuroprotection? - PubMed (original) (raw)

Review

doi: 10.1093/bmb/ldh036. Print 2004.

Affiliations

• PMID: 15684247
• DOI: 10.1093/bmb/ldh036

Review

alpha2-Adrenoceptor agonists: shedding light on neuroprotection?

Daqing Ma et al. Br Med Bull. 2005.

Abstract

Although alpha(2)-adrenoceptor agonists are widely used for analgesia, anxiolysis, sedation, sympatholysis and as anaesthetic-adjuncts for many years, their potential use as neuroprotectants has so far been confined to laboratory experiments. Despite the large body of evidence from both in vivo and in vitro studies, their exact neuroprotective mechanisms remain elusive. Herein, we review the available literature pertaining to the neuroprotective effect of alpha(2)-adrenoceptor agonists and the possible biochemical and physiological cascades involved in their mechanisms of action. The remarkable safety profile of alpha(2)-adrenoceptor agonists and their high potency of neuroprotection should prompt clinical trials to evaluate their neuroprotective efficacy in humans.

PubMed Disclaimer

Comment in

• Preventing delirium: beyond dexmedetomidine - Authors' reply.
  Su X, Wang DX, Ma D. Su X, et al. Lancet. 2017 Mar 11;389(10073):1009-1010. doi: 10.1016/S0140-6736(17)30658-X. Lancet. 2017. PMID: 28290992 No abstract available.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database