Scheduling of revaccination against hepatitis B virus - PubMed (original) (raw)
Scheduling of revaccination against hepatitis B virus
P Coursaget et al. Lancet. 1991.
Abstract
Studies have shown that to maintain protection against infection after a primary course of hepatitis B immunisation, revaccination can be scheduled on the basis of an anti-hepatitis B virus surface antigen (anti-HBs) titre obtained 1 month after the booster dose. However, schemes which require post-booster testing may present practical difficulties. We applied a random-effects regression model to data from 118 Senegalese infants given three injections of hepatitis B vaccine about 6 weeks apart and a booster injection at 13 months, and show that revaccination can be scheduled on the basis of an anti-HBs titre recorded at the time of the booster dose. We also show that titre-at-booster is no less accurate in predicting future titre than 1-month post-booster titre. In several other studies the post-booster decline in anti-HBs conforms to the same mathematical description, indicating the generality of our findings.
Comment in
- Revaccination against hepatitis B.
[No authors listed] [No authors listed] Lancet. 1991 Jul 6;338(8758):61-2. Lancet. 1991. PMID: 1676120 No abstract available. - Revaccination against hepatitis B virus.
de Brouwer C, Lecomte A. de Brouwer C, et al. Lancet. 1991 Aug 3;338(8762):319. doi: 10.1016/0140-6736(91)90461-w. Lancet. 1991. PMID: 1677140 No abstract available.
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