Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains - PubMed (original) (raw)
. 1990 Nov 29;348(6300):411-8.
doi: 10.1038/348411a0.
Affiliations
- PMID: 1701030
- DOI: 10.1038/348411a0
Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains
J H Wang et al. Nature. 1990.
Abstract
The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface.
Comment in
- Immunology. One hand clapping.
Travers P. Travers P. Nature. 1990 Nov 29;348(6300):393-4. doi: 10.1038/348393a0. Nature. 1990. PMID: 2247144 No abstract available.
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