Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression - PubMed (original) (raw)
Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression
Christina L Fales et al. Biol Psychiatry. 2008.
Abstract
Background: Major depression is characterized by a negativity bias: an enhanced responsiveness to, and memory for, affectively negative stimuli. However, it is not yet clear whether this bias represents 1) impaired top-down cognitive control over affective responses, potentially linked to deficits in dorsolateral prefrontal cortex function; or 2) enhanced bottom-up responses to affectively laden stimuli that dysregulate cognitive control mechanisms, potentially linked to deficits in amygdala and anterior cingulate function.
Methods: We used an attentional interference task using emotional distracters to test for top-down versus bottom-up dysfunction in the interaction of cognitive-control circuitry and emotion-processing circuitry. A total of 27 patients with major depression and 24 control participants was tested. Event-related functional magnetic resonance imaging was carried out as participants directly attended to, or attempted to ignore, fear-related stimuli.
Results: Compared with control subjects, patients with depression showed an enhanced amygdala response to unattended fear-related stimuli (relative to unattended neutral). By contrast, control participants showed increased activity in right dorsolateral prefrontal cortex (Brodmann areas 46/9) when ignoring fear stimuli (relative to neutral), which the patients with depression did not show. In addition, the depressed participants failed to show evidence of error-related cognitive adjustments (increased activity in bilateral dorsolateral prefrontal cortex on posterror trials), but the control group did show them.
Conclusions: These results suggest multiple sources of dysregulation in emotional and cognitive control circuitry in depression, implicating both top-down and bottom-up dysfunction.
Figures
Figure 1
Example of a stimulus screen used in the emotional conflict task.
Figure 2
Areas in the left amygdala (a) and right dorsolateral prefrontal cortex (b) showing a significant three-way interaction of attention × emotion × group. Graphs show percent change in signal magnitude for the fear-minus-neutral contrast in each region. Error bars show standard errors of the mean.
Figure 3
Areas in left (a) and right (b) dorsolateral prefrontal cortex showing significant group differences in the post-error effect: interaction of trial-type (post-correct versus post-error) × group. Graphs show percent change in signal magnitude for each region. Error bars show standard errors of the mean.
Figure 4
Areas in the subgenual anterior cingulate (a) and superior-rostral anterior cingulate (c) show significant group differences across all conditions. Areas in pregenual cingulate (b) show significant differences in a group × attention interaction, where controls had less deactivation in the attend-to-faces conditions (left side of graph) while depressed had less deactivation in the ignore-faces conditions (right side of graph). Graphs show percent change in signal magnitude for each region. Error bars show standard errors of the mean.
Similar articles
- Depressive state- and disease-related alterations in neural responses to affective and executive challenges in geriatric depression.
Wang L, Krishnan KR, Steffens DC, Potter GG, Dolcos F, McCarthy G. Wang L, et al. Am J Psychiatry. 2008 Jul;165(7):863-71. doi: 10.1176/appi.ajp.2008.07101590. Epub 2008 May 1. Am J Psychiatry. 2008. PMID: 18450929 - Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features.
Siegle GJ, Thompson W, Carter CS, Steinhauer SR, Thase ME. Siegle GJ, et al. Biol Psychiatry. 2007 Jan 15;61(2):198-209. doi: 10.1016/j.biopsych.2006.05.048. Epub 2006 Oct 6. Biol Psychiatry. 2007. PMID: 17027931 - Altered functional interaction hub between affective network and cognitive control network in patients with major depressive disorder.
Wang YL, Yang SZ, Sun WL, Shi YZ, Duan HF. Wang YL, et al. Behav Brain Res. 2016 Feb 1;298(Pt B):301-9. doi: 10.1016/j.bbr.2015.10.040. Epub 2015 Oct 28. Behav Brain Res. 2016. PMID: 26519557 - A review of fMRI studies during visual emotive processing in major depressive disorder.
Jaworska N, Yang XR, Knott V, MacQueen G. Jaworska N, et al. World J Biol Psychiatry. 2015 Oct;16(7):448-71. doi: 10.3109/15622975.2014.885659. Epub 2014 Mar 17. World J Biol Psychiatry. 2015. PMID: 24635551 Review. - Top-down and bottom-up factors in threat-related perception and attention in anxiety.
Sussman TJ, Jin J, Mohanty A. Sussman TJ, et al. Biol Psychol. 2016 Dec;121(Pt B):160-172. doi: 10.1016/j.biopsycho.2016.08.006. Epub 2016 Aug 18. Biol Psychol. 2016. PMID: 27546616 Review.
Cited by
- Convergent functional effects of antidepressants in major depressive disorder: a neuroimaging meta-analysis.
Saberi A, Ebneabbasi A, Rahimi S, Sarebannejad S, Sen ZD, Graf H, Walter M, Sorg C, Camilleri JA, Laird AR, Fox PT, Valk SL, Eickhoff SB, Tahmasian M. Saberi A, et al. Mol Psychiatry. 2024 Oct 15. doi: 10.1038/s41380-024-02780-6. Online ahead of print. Mol Psychiatry. 2024. PMID: 39406999 - Intracranial Directed Connectivity Links Subregions of the Prefrontal Cortex to Major Depression.
Myers J, Xiao J, Mathura R, Shofty B, Pirtle V, Adkinson J, Allawala AB, Anand A, Gadot R, Najera R, Rey HG, Mathew SJ, Bijanki K, Banks G, Watrous A, Bartoli E, Heilbronner SR, Provenza N, Goodman WK, Pouratian N, Hayden BY, Sheth SA. Myers J, et al. medRxiv [Preprint]. 2024 Aug 8:2024.08.07.24311546. doi: 10.1101/2024.08.07.24311546. medRxiv. 2024. PMID: 39148826 Free PMC article. Preprint. - Transcranial direct current stimulation over the right parietal cortex improves the depressive disorder: A preliminary study.
Guo X, Zhou Q, Lu Y, Xu Z, Wen Z, Gu P, Tian S, Wang Y. Guo X, et al. Brain Behav. 2024 Aug;14(8):e3638. doi: 10.1002/brb3.3638. Brain Behav. 2024. PMID: 39099388 Free PMC article. - The Human Connectome Project of adolescent anxiety and depression dataset.
Hubbard NA, Bauer CCC, Siless V, Auerbach RP, Elam JS, Frosch IR, Henin A, Hofmann SG, Hodge MR, Jones R, Lenzini P, Lo N, Park AT, Pizzagalli DA, Vaz-DeSouza F, Gabrieli JDE, Whitfield-Gabrieli S, Yendiki A, Ghosh SS. Hubbard NA, et al. Sci Data. 2024 Aug 2;11(1):837. doi: 10.1038/s41597-024-03629-x. Sci Data. 2024. PMID: 39095370 Free PMC article. - Changes in interoceptive accuracy related to emotional interference in somatic symptom disorder.
Lee D, Kim SJ, Cheon J, Jung YC, Kang JI. Lee D, et al. BMC Psychol. 2024 May 17;12(1):279. doi: 10.1186/s40359-024-01778-7. BMC Psychol. 2024. PMID: 38755731 Free PMC article.
References
- Williams JMG, Oaksford M. Cognitive science, anxiety, and depression: From experiments to connectionism. In: Young S, editor. Cognitive science and the clinical disorders. San Diego, CA: Academic Press; 1992.
- Norman WH, Miller IW, Dow MG. Characteristics of depressed patients with elevated levels of dysfunctional cognitions. Cognitive Therapy and Research. 1988;12:39–52.
- Wenzlaff RM, Wegner DM, Roper DW. Depression and mental control: The resurgence of unwanted negative thoughts. Journal of Personality and Social Psychology. 1988;55:882–892. - PubMed
- Mogg K, Bradley BP, Williams R. Attentional bias in anxiety and depression: The role of awareness. British Journal of Clinical Psychology. 1995;34(1):17–36. - PubMed
- Ochsner K, Gross JJ. The cognitive control of emotion. Trends in Cognitive Science. 2005;9(5):242–249. - PubMed
Publication types
MeSH terms
Grants and funding
- R01 MH64821/MH/NIMH NIH HHS/United States
- R01 MH064821-03/MH/NIMH NIH HHS/United States
- K24 RR018192/RR/NCRR NIH HHS/United States
- R01 MH064821-01A2/MH/NIMH NIH HHS/United States
- K24 RR018192-03/RR/NCRR NIH HHS/United States
- R01 MH064821-02S1/MH/NIMH NIH HHS/United States
- K24 RR018192-04/RR/NCRR NIH HHS/United States
- R01 MH06603101/MH/NIMH NIH HHS/United States
- R01 MH064821/MH/NIMH NIH HHS/United States
- K24 RR018192-01/RR/NCRR NIH HHS/United States
- K24 RR18192/RR/NCRR NIH HHS/United States
- K24 RR018192-05/RR/NCRR NIH HHS/United States
- R01 MH064821-02/MH/NIMH NIH HHS/United States
- R01 MH064821-04/MH/NIMH NIH HHS/United States
- K24 RR018192-02/RR/NCRR NIH HHS/United States
LinkOut - more resources
Full Text Sources