Activity and safety profile of low-dose rituximab for the treatment of autoimmune cytopenias in adults - PubMed (original) (raw)
Multicenter Study
. 2007 Dec;92(12):1695-8.
doi: 10.3324/haematol.11709.
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- PMID: 18055995
- DOI: 10.3324/haematol.11709
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Multicenter Study
Activity and safety profile of low-dose rituximab for the treatment of autoimmune cytopenias in adults
Drew Provan et al. Haematologica. 2007 Dec.
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Abstract
We conducted a retrospective analysis of 11 consecutive patients with various autoimmune cytopenias who failed to respond to conventional treatments and received a fixed-dose regimen of rituximab (100 mg weekly for 4 consecutive weeks). Sustained complete responses were achieved in 4 out of 7 patients with idiopathic thrombocytopenic purpura and in 1 patient with autoimmune pancytopenia. A partial response was observed in 1 patient with autoimmune hemolytic anemia. The immunotherapy had no effect in 1 patient with pure red cell aplasia or in 1 patient with autoimmune neutropenia. No infusion-related or delayed toxicities attributable to rituximab were experienced by any of the patients.
Comment in
- Rituximab for the treatment of autoimmune cytopenias.
Berentsen S. Berentsen S. Haematologica. 2007 Dec;92(12):1589-96. doi: 10.3324/haematol.11312. Haematologica. 2007. PMID: 18055980 No abstract available.
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