Behavioural signs of depression and apoptosis in the limbic system following myocardial infarction: effects of sertraline - PubMed (original) (raw)
Behavioural signs of depression and apoptosis in the limbic system following myocardial infarction: effects of sertraline
B P Wann et al. J Psychopharmacol. 2009 Jun.
Abstract
Depression is diagnosed in 15-30% of patients following myocardial infarction (MI) and this may also be observed in the rat. We measured the effects of the antidepressant sertraline on behavioural and biochemical events following MI in a rat model. Following surgery, MI rats and sham controls were treated with sertraline (10 mg/kg, i.p.) or saline. Subgroups of rats were tested for behavioural depression 14 days after surgery. Apoptosis was estimated in other rats by measuring caspase-3 activity and TUNEL positive cells (3 days after surgery) in limbic structures (amygdale, hippocampus, hypothalamus, frontal and prefrontal cortices). Bax/Bcl-2 ratio was measured 14 days after surgery. Behavioural signs of depression (decreased sucrose intake and forced swimming time) were found in saline-treated MI rats but not in sertraline-treated rats. Compared with controls, caspase-3 activity and TUNEL positive cells were significantly increased in most limbic structures of MI rats. High prefrontal Bax/Bcl-2 ratio in MI rats correlated with low forced swimming time. Apoptosis was not found in sertraline-treated MI rats. These results establish the bases of a rat model of depression following MI and show for the first time that a selective serotonin reuptake inhibitor prevents both behavioural and biochemical markers in this model.
Similar articles
- Vulnerability for apoptosis in the limbic system after myocardial infarction in rats: a possible model for human postinfarct major depression.
Wann BP, Bah TM, Boucher M, Courtemanche J, Le Marec N, Rousseau G, Godbout R. Wann BP, et al. J Psychiatry Neurosci. 2007 Jan;32(1):11-6. J Psychiatry Neurosci. 2007. PMID: 17245469 Free PMC article. - Lactobacillus helveticus and Bifidobacterium longum taken in combination reduce the apoptosis propensity in the limbic system after myocardial infarction in a rat model.
Girard SA, Bah TM, Kaloustian S, Lada-Moldovan L, Rondeau I, Tompkins TA, Godbout R, Rousseau G. Girard SA, et al. Br J Nutr. 2009 Nov;102(10):1420-5. doi: 10.1017/S0007114509990766. Epub 2009 Jun 29. Br J Nutr. 2009. PMID: 19563693 - Apoptosis time course in the limbic system after myocardial infarction in the rat.
Kaloustian S, Wann BP, Bah TM, Girard SA, Apostolakis A, Ishak S, Mathieu S, Ryvlin P, Godbout R, Rousseau G. Kaloustian S, et al. Brain Res. 2008 Jun 24;1216:87-91. doi: 10.1016/j.brainres.2008.04.019. Epub 2008 Apr 18. Brain Res. 2008. PMID: 18495089 - [Pharmacological treatment of depression after acute myocardial infarction].
Fasullo S, Puccio D, Fasullo S, Novo S. Fasullo S, et al. Ital Heart J Suppl. 2004 Nov;5(11):839-46. Ital Heart J Suppl. 2004. PMID: 15633427 Review. Italian. - [Depression following myocardial infarction].
Vaahtovuo M, Saarijärvi S. Vaahtovuo M, et al. Duodecim. 1998;114(21):2169-73. Duodecim. 1998. PMID: 11757104 Review. Finnish. No abstract available.
Cited by
- Downregulation of interleukin-1 beta via Jmjd3 inhibition improves post-myocardial infarction depression.
Tang X, Liu R, Zhang Y, Zhu L, Shi W, Shan Y, Wu S, Li Y, Liu G, Ma W. Tang X, et al. Cardiovasc Diagn Ther. 2022 Jun;12(3):340-351. doi: 10.21037/cdt-21-724. Cardiovasc Diagn Ther. 2022. PMID: 35800354 Free PMC article. - Effect of m-Trifluoromethyl-diphenyl diselenide on the Pain-Depression Dyad Induced by Reserpine: Insights on Oxidative Stress, Apoptotic, and Glucocorticoid Receptor Modulation.
Schossler Garcia C, Garcia PR, da Silva Espíndola CN, Nunes GD, Jardim NS, Müller SG, Bortolatto CF, Brüning CA. Schossler Garcia C, et al. Mol Neurobiol. 2021 Oct;58(10):5078-5089. doi: 10.1007/s12035-021-02483-x. Epub 2021 Jul 10. Mol Neurobiol. 2021. PMID: 34245440 - Alterations of medial prefrontal cortex bioelectrical activity in experimental model of isoprenaline-induced myocardial infarction.
Vorkapić M, Savić A, Janković M, Useinović N, Isaković M, Puškaš N, Stanojlović O, Hrnčić D. Vorkapić M, et al. PLoS One. 2020 May 8;15(5):e0232530. doi: 10.1371/journal.pone.0232530. eCollection 2020. PLoS One. 2020. PMID: 32384091 Free PMC article. - Protective effect of epigallocatechin-3-gallate against neuroinflammation and anxiety-like behavior in a rat model of myocardial infarction.
Wang J, Li P, Qin T, Sun D, Zhao X, Zhang B. Wang J, et al. Brain Behav. 2020 Jun;10(6):e01633. doi: 10.1002/brb3.1633. Epub 2020 Apr 18. Brain Behav. 2020. PMID: 32304289 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials