Emergence of stereotypies in juvenile monkeys (Macaca mulatta) with neonatal amygdala or hippocampus lesions - PubMed (original) (raw)

Emergence of stereotypies in juvenile monkeys (Macaca mulatta) with neonatal amygdala or hippocampus lesions

M D Bauman et al. Behav Neurosci. 2008 Oct.

Abstract

The emergence of stereotypies was examined in juvenile rhesus monkeys (Macaca mulatta) who, at 2 weeks of postnatal age, received selective bilateral ibotenic acid lesions of the amygdala (N = 8) or hippocampus (N = 8). The lesion groups were compared to age-matched control subjects that received a sham surgical procedure (N = 8). All subjects were maternally reared for the first 6 months and provided access to social groups throughout development. Pronounced stereotypies were not observed in any of the experimental groups during the first year of life. However, between 1 to 2 years of age, both amygdala- and hippocampus-lesioned subjects began to exhibit stereotypies. When observed as juveniles, both amygdala- and hippocampus-lesioned subjects consistently produced more stereotypies than the control subjects in a variety of contexts. More interesting, neonatal lesions of either the amygdala or hippocampus resulted in unique repertoires of repetitive behaviors. Amygdala-lesioned subjects exhibited more self-directed stereotypies and the hippocampus-lesioned subjects displayed more head-twisting. We discuss these results in relation to the neurobiological basis of repetitive stereotypies in neurodevelopmental disorders, such as autism.

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Figures

Figure 1

Figure 1

Graph illustrating frequency of stereotypies produced across all behavioral contexts (Mean +/− SEM per 5 min observation period) for all stereotypies combined. Asterisks denote significant post hoc Fisher PLSD test (p< .05).

Figure 2

Figure 2

Graph illustrating frequency of stereotypies produced across all behavioral contexts (Mean +/− SEM per 5 min observation period) divided into categories of repetitive behaviors: a) whole body stereotypies, b) self-directed stereotypies, c) head-twist stereotypies. Asterisks denote significant post hoc Fisher PLSD test (p< .05).

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