Glycemic index, cholecystokinin, satiety and disinhibition: is there an unappreciated paradox for overweight women? - PubMed (original) (raw)
Randomized Controlled Trial
. 2008 Nov;32(11):1647-54.
doi: 10.1038/ijo.2008.159. Epub 2008 Sep 30.
Affiliations
- PMID: 18825157
- DOI: 10.1038/ijo.2008.159
Randomized Controlled Trial
Glycemic index, cholecystokinin, satiety and disinhibition: is there an unappreciated paradox for overweight women?
B M Burton-Freeman et al. Int J Obes (Lond). 2008 Nov.
Abstract
Background: The clinical utility of a low glycemic index (LGI) diet for appetite and food intake control is controversial. Complicating the issue are psychological and behavioral influences related to eating.
Objective: The aim of this study was to investigate the satiety and glycemic response to high GI (HGI) and LGI meals in overweight restrained (R, n=12) and unrestrained (UR, n=10) women.
Design and measurements: In a randomized crossover study, subjective satiety, cholecystokinin (CCK), glucose, insulin, triacylglyceride (TG) and free fatty acids (FFAs) were measured at defined intervals for 8 h after the participants consumed HGI or LGI test meals. Test meals were matched for energy, energy density, macronutrient content and available carbohydrate, but differed by carbohydrate source; refined grain versus whole grain, respectively.
Results: The HGI meal resulted in greater satiety overall, suppressing hunger, desire to eat and prospective consumption compared with the LGI (P<0.01) meal. Plasma CCK was significantly elevated after the HGI meal compared with the LGI meal (P<0.001). Plasma glucose, insulin and TG were higher and FFAs were lower after the HGI meal compared with the LGI meal (P<0001). Dietary restraint did not significantly influence CCK (P=0.14) or subjective satiety (P>0.4); however, an interaction of restraint and disinhibition on CCK was apparent. CCK was blunted in R participants with higher disinhibition scores than UR or R participants with lower disinhibition scores (P<0.05).
Conclusions: A LGI diet may not be suitable for optimal satiety and appetite control in overweight women. The relationship between cognitive influences of eating and biobehavioral outcomes requires further investigation.
Similar articles
- Impact of overweight and glucose tolerance on postprandial responses to high- and low-glycaemic index meals.
Perälä MM, Hätönen KA, Virtamo J, Eriksson JG, Sinkko HK, Sundvall J, Valsta LM. Perälä MM, et al. Br J Nutr. 2011 Jun;105(11):1627-34. doi: 10.1017/S0007114510005477. Epub 2011 Jan 25. Br J Nutr. 2011. PMID: 21262063 Clinical Trial. - Effect of breakfast glycemic index on metabolic responses during rest and exercise in overweight and non-overweight adolescent girls.
Zakrzewski JK, Stevenson EJ, Tolfrey K. Zakrzewski JK, et al. Eur J Clin Nutr. 2012 Apr;66(4):436-42. doi: 10.1038/ejcn.2011.175. Epub 2011 Oct 5. Eur J Clin Nutr. 2012. PMID: 21970942 - Beneficial effects of a 5-week low-glycaemic index regimen on weight control and cardiovascular risk factors in overweight non-diabetic subjects.
de Rougemont A, Normand S, Nazare JA, Skilton MR, Sothier M, Vinoy S, Laville M. de Rougemont A, et al. Br J Nutr. 2007 Dec;98(6):1288-98. doi: 10.1017/S0007114507778674. Epub 2007 Jul 9. Br J Nutr. 2007. PMID: 17617942 Clinical Trial. - Associations between postprandial insulin and blood glucose responses, appetite sensations and energy intake in normal weight and overweight individuals: a meta-analysis of test meal studies.
Flint A, Gregersen NT, Gluud LL, Møller BK, Raben A, Tetens I, Verdich C, Astrup A. Flint A, et al. Br J Nutr. 2007 Jul;98(1):17-25. doi: 10.1017/S000711450768297X. Epub 2007 May 25. Br J Nutr. 2007. PMID: 17524176 Review. - Glycemic index and satiety.
Roberts SB. Roberts SB. Nutr Clin Care. 2003 Jan-Apr;6(1):20-6. Nutr Clin Care. 2003. PMID: 12841427 Review.
Cited by
- Low-glycemic load decreases postprandial insulin and glucose and increases postprandial ghrelin in white but not black women.
Brownley KA, Heymen S, Hinderliter AL, Galanko J, Macintosh B. Brownley KA, et al. J Nutr. 2012 Jul;142(7):1240-5. doi: 10.3945/jn.111.146365. Epub 2012 May 30. J Nutr. 2012. PMID: 22649264 Free PMC article. Clinical Trial. - The association between carbohydrate quality index and anthropometry, blood glucose, lipid profile and blood pressure in people with type 1 diabetes mellitus: a cross-sectional study in Iran.
Jebraeili H, Shabbidar S, Sajjadpour Z, Aghdam SD, Qorbani M, Rajab A, Sotoudeh G. Jebraeili H, et al. J Diabetes Metab Disord. 2021 Nov 13;20(2):1349-1358. doi: 10.1007/s40200-021-00864-6. eCollection 2021 Dec. J Diabetes Metab Disord. 2021. PMID: 34900786 Free PMC article. - Eating disinhibition and vagal tone moderate the postprandial response to glycemic load: a randomised controlled trial.
Young HA, Watkins H. Young HA, et al. Sci Rep. 2016 Oct 20;6:35740. doi: 10.1038/srep35740. Sci Rep. 2016. PMID: 27761024 Free PMC article. Clinical Trial. - Effect of glycemic load on peptide-YY levels in a biracial sample of obese and normal weight women.
Brownley KA, Heymen S, Hinderliter AL, MacIntosh B. Brownley KA, et al. Obesity (Silver Spring). 2010 Jul;18(7):1297-303. doi: 10.1038/oby.2009.368. Epub 2009 Oct 29. Obesity (Silver Spring). 2010. PMID: 19875990 Free PMC article. - Pulse consumption, satiety, and weight management.
McCrory MA, Hamaker BR, Lovejoy JC, Eichelsdoerfer PE. McCrory MA, et al. Adv Nutr. 2010 Nov;1(1):17-30. doi: 10.3945/an.110.1006. Epub 2010 Nov 16. Adv Nutr. 2010. PMID: 22043448 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous