A concise asymmetric total synthesis of aspidophytine - PubMed (original) (raw)

. 2008 Nov 12;130(45):14942-3.

doi: 10.1021/ja806176w. Epub 2008 Oct 15.

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A concise asymmetric total synthesis of aspidophytine

K C Nicolaou et al. J Am Chem Soc. 2008.

Abstract

An expedient asymmetric total synthesis of aspidophytine is reported. A highly convergent strategy involving the sequential annulation of vinyl iodide 5 with indole 6 exploits varying modes of indole reactivity to provide aspidophytine in 23% over six steps from 5.

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