DNA transportation authority - PubMed (original) (raw)

DNA transportation authority

Delphine J Lee et al. Nat Med. 2008 Dec.

No abstract available

PubMed Disclaimer

Figures

Figure 1

Figure 1

Transportation authority for nucleic acids. As part of the danger response to injury, cathelicidin transports nucleic acids released from damaged cells to TLRs located in endosomes, activating appropriate pathways of inflammation. If the production of cathelicidin is dysregulated in the presence of plasmacytoid dendritic cells, autoimmune phenomenon may occur. As part of the innate immune response to microbial infection, the TLR-induced, vitamin D-dependent production of cathelicidin and the release of microbial nucleic acids may further activate TLRs located in endosomes, thereby amplifying host defense pathways. APC, antigen-presenting cell; pDC; plasmacytoid dendritic cell.

References

    1. Lande R, et al. Nature. 2007;449:564–569. -PubMed
    1. Kuner N, Hartschuh W, Khan-Durani B. Hautarzt. 2003;54:274–278. -PubMed
    1. Ong PY, et al. N. Engl. J. Med. 2002;347:1151–1160. -PubMed
    1. Schauber J, et al. J. Clin. Invest. 2007;117:803–811. -PMC -PubMed
    1. Liu PT, et al. Science. 2006;311:1770–1773. -PubMed

MeSH terms

Substances

LinkOut - more resources