Trans-fatty acids and nonlipid risk factors - PubMed (original) (raw)

Review

Trans-fatty acids and nonlipid risk factors

Sarah K Wallace et al. Curr Atheroscler Rep. 2009 Nov.

Abstract

Consumption of industrially produced trans-fatty acids (TFA) is associated with substantial risk of coronary heart disease (CHD). The magnitude of this relationship, as well as emerging associations with end points such as diabetes and sudden cardiac death, cannot be fully explained by the well-established adverse effects of TFA on serum lipids. We review the evidence for effects of TFA intake on nonlipid risk factors. Based on evidence from randomized controlled trials, observational studies, animal experiments, and in vitro studies, these include effects on systemic inflammation, endothelial dysfunction, visceral adiposity, insulin resistance, and arrhythmic risk. The types and strength of evidence for each of these nonlipid effects varies, but the overall constellation of findings is qualitatively and quantitatively unique among dietary fats. The multiple adverse effects and implicated pathways are consistent with the observed strong associations of TFA consumption with CHD risk. These nonlipid effects also explain why TFA consumption may adversely impact other non-CHD diseases and end points.

PubMed Disclaimer

Similar articles

• Health effects of trans-fatty acids: experimental and observational evidence.
  Mozaffarian D, Aro A, Willett WC. Mozaffarian D, et al. Eur J Clin Nutr. 2009 May;63 Suppl 2:S5-21. doi: 10.1038/sj.ejcn.1602973. Eur J Clin Nutr. 2009. PMID: 19424218 Review.
• Trans fatty acids and cardiovascular risk: a unique cardiometabolic imprint?
  Mozaffarian D, Willett WC. Mozaffarian D, et al. Curr Atheroscler Rep. 2007 Dec;9(6):486-93. doi: 10.1007/s11883-007-0065-9. Curr Atheroscler Rep. 2007. PMID: 18377789 Review.
• Consumption and health effects of trans fatty acids: a review.
  Teegala SM, Willett WC, Mozaffarian D. Teegala SM, et al. J AOAC Int. 2009 Sep-Oct;92(5):1250-7. J AOAC Int. 2009. PMID: 19916363 Review.
• Intake of ruminant trans fatty acids and risk of coronary heart disease-an overview.
  Jakobsen MU, Bysted A, Andersen NL, Heitmann BL, Hartkopp HB, Leth T, Overvad K, Dyerberg J. Jakobsen MU, et al. Atheroscler Suppl. 2006 May;7(2):9-11. doi: 10.1016/j.atherosclerosissup.2006.04.004. Epub 2006 May 18. Atheroscler Suppl. 2006. PMID: 16713389 Review.
• Trans fatty acids - effects on systemic inflammation and endothelial function.
  Mozaffarian D. Mozaffarian D. Atheroscler Suppl. 2006 May;7(2):29-32. doi: 10.1016/j.atherosclerosissup.2006.04.007. Epub 2006 May 18. Atheroscler Suppl. 2006. PMID: 16713393 Review.

Cited by

• Effects of a High Trans Fatty Acid Diet on Kidney-, Liver-, and Heart-Associated Diseases in a Rabbit Model.
  Ismail H, Mubashar Z, Khan H, Naveed Z, Dilshad E, Bhatti MZ, Anwaar S, Saleem S, Mehmood S, Rahman A, Rashid U, Fouad D, De Waard M, Batiha GE. Ismail H, et al. Metabolites. 2024 Aug 8;14(8):442. doi: 10.3390/metabo14080442. Metabolites. 2024. PMID: 39195538 Free PMC article.
• Association of plasma trans fatty acid concentrations with blood pressure and hypertension in U.S. adults.
  Luan M, Tian Y, Yan D, Liang S. Luan M, et al. Front Endocrinol (Lausanne). 2024 Apr 22;15:1373095. doi: 10.3389/fendo.2024.1373095. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38711984 Free PMC article.
• Population food intake clusters and cardiovascular disease incidence: a Bayesian quantifying of a prospective population-based cohort study in a low and middle-income country.
  Rikhtehgaran R, Shamsi K, Renani EM, Arab A, Nouri F, Mohammadifard N, Marateb HR, Mansourian M, Sarrafzadegan N. Rikhtehgaran R, et al. Front Nutr. 2023 Jul 13;10:1150481. doi: 10.3389/fnut.2023.1150481. eCollection 2023. Front Nutr. 2023. PMID: 37521422 Free PMC article.
• The association between fatty acid quality indices and quality of life among overweight and obese women: A cross-sectional study.
  Rasaei N, Daneshzad E, Soveid N, Clark CCT, Mirzaei K. Rasaei N, et al. Front Public Health. 2023 Jan 26;10:1030726. doi: 10.3389/fpubh.2022.1030726. eCollection 2022. Front Public Health. 2023. PMID: 36777780 Free PMC article.
• Prenatal exposure to trans fatty acids and head growth in fetal life and childhood: triangulating confounder-adjustment and instrumental variable approaches.
  Zou R, Labrecque JA, Swanson SA, Steegers EAP, White T, El Marroun H, Tiemeier H. Zou R, et al. Eur J Epidemiol. 2022 Nov;37(11):1171-1180. doi: 10.1007/s10654-022-00910-4. Epub 2022 Sep 15. Eur J Epidemiol. 2022. PMID: 36107361 Free PMC article.

References

1. 1. Am J Clin Nutr. 2008 Oct;88(4):913-21 - PubMed
2. 1. Nat Rev Endocrinol. 2009 Jun;5(6):335-44 - PubMed
3. 1. Am J Clin Nutr. 1999 Nov;70(5):832-8 - PubMed
4. 1. Gynecol Obstet Invest. 1998 Aug;46(2):84-7 - PubMed
5. 1. Ann Nutr Metab. 2008;53(2):129-36 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Medical

  • MedlinePlus Health Information