Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

Anthony C Ruocco et al. Psychiatry Res. 2010.

Abstract

Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n=10) and matched non-psychiatric comparison subjects (n=10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

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Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder - PubMed (original) (raw)