Leukocyte membrane bleb and pseudopod formation in hypertension - PubMed (original) (raw)

Leukocyte membrane bleb and pseudopod formation in hypertension

K M Edwards et al. J Hum Hypertens. 2010 Oct.

Abstract

Leukocyte activation, including adhesion molecule expression, oxygen radical generation and, in animal studies, pseudopod formation, is a hallmark of hypertension. This study examined pseudopod and bleb formation and demonstrates that leukocytes from hypertensive individuals are more susceptible to produce membrane blebs than leukocytes from normotensive individuals. Bleb formation is likely indicative of apoptosis, thus this observation adds to previous observations of increased apoptosis in various tissues in hypertension.

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Figures

Figure 1

Association between resting blood pressure (SBP upper panel, DBP lower panel) and % cells showing bleb formation at pre-exercise. Insert; pseudopod(PP) and bleb(B) morphology.

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Leukocyte membrane bleb and pseudopod formation in hypertension - PubMed (original) (raw)