Substructural hippocampal glucose metabolism observed on PET/MRI - PubMed (original) (raw)
. 2010 Oct;51(10):1545-8.
doi: 10.2967/jnumed.110.076182. Epub 2010 Sep 16.
Affiliations
- PMID: 20847161
- DOI: 10.2967/jnumed.110.076182
Free article
Substructural hippocampal glucose metabolism observed on PET/MRI
Zang-Hee Cho et al. J Nucl Med. 2010 Oct.
Free article
Abstract
The hippocampus is one of the best-known neural structures in the brain and has been of interest in observing the substructures and their metabolic functions. However, it has been difficult to distinguish its substructures and functions in vivo because of its small size.
Methods: (18)F-FDG PET and high-resolution MRI of the hippocampus were performed on 5 healthy subjects using a PET/MRI system. The metabolism of each hippocampal substructure was measured in vivo on the basis of the MR images.
Results: The dentate gyrus and cornu ammonis 4 showed the highest glucose uptake in the healthy subjects.
Conclusion: Measuring glucose metabolism in the substructures of the hippocampus could provide a new tool for the future investigation of related brain diseases or functional studies, such as Alzheimer disease or memory and learning studies.
Comment in
- Horizontal versus longitudinal axis of the hippocampus: metabolic differentiation as measured with high-resolution PET/MRI.
Yakushev I, Fellgiebel A. Yakushev I, et al. J Nucl Med. 2011 Feb;52(2):329; author reply 329-30. doi: 10.2967/jnumed.110.085084. Epub 2011 Jan 13. J Nucl Med. 2011. PMID: 21233184 No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical