The effect of glutamine on murine splenic leukocyte responses to T and B cell mitogens - PubMed (original) (raw)

. 1990 Dec:68 ( Pt 6):405-8.

doi: 10.1038/icb.1990.54.

Affiliations

• PMID: 2097296
• DOI: 10.1038/icb.1990.54

The effect of glutamine on murine splenic leukocyte responses to T and B cell mitogens

M Griffiths et al. Immunol Cell Biol. 1990 Dec.

Abstract

Murine splenic leukocytes cannot be stimulated to synthesize [3H]-DNA by various concentrations of either the T cell mitogens, Concanavalin-A (Con-A) or phytohaemagglutinin (PHA) or the B cell mitogen, lipopolysaccharide (LPS), unless glutamine is present in the culture medium. The optimum concentration of the T cell mitogens (Con-A, PHA) remained constant for all levels of glutamine while that of the B cell mitogen (LPS) increased as the concentration of glutamine in the medium increased.

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