A novel family of biodegradable poly(ester amide) elastomers - PubMed (original) (raw)

A novel family of biodegradable poly(ester amide) elastomers

Hao Cheng et al. Adv Mater. 2011.

No abstract available

PubMed Disclaimer

Figures

Figure 1

Figure 1

Mechanical properties of poly(ester amide) elastomers. Representative stress-strain curves of dehydrated and hydrated PGSDHP 30% A), PGSDMP 30% B), PGS-12C10% C). Summary of poly(ester amide) elastomers D) Young’s modulus, E) ultimate tensile strain and F) ultimate tensile stress.

Figure 2

Figure 2

In vitro and in vivo biocompatibility of poly(ester amide) elastomers. A) Phase-contrast images of HUVECs after 24 h of growth on elastomeric materials. Lamellipodia are marked by red arrows, while long cell protrusions are highlighted by yellow arrows. The scale bar represents 100 μm. B) An AlamarBlue assay was used to quantify the viability and proliferation of cells on different materials. Fluorescence intensity is proportional to the number of cells. PLGA and PGS served as controls. C) Representative images of H&E stained sections of subcutaneously implanted materials with surrounding tissues. Samples were harvested at 2 weeks, 1 month and 2 months following implantation. The regions of skin muscles, fibrous inflammatory zone and polymers are indicated by M, F, and P, respectively. The scale bar is 100 μm. D) Quantification of the in vivo biocompatibility by measurement of capsule thickness surrounding each implant. The thickness of the original fat tissue in between the dense inflammatory zone and skin muscle is not included.

Scheme 1

Scheme 1

Synthetic scheme for poly(ester amide)s. Diamine X is incorporated in the polymer bone via amide bonds. R can be H or polymer segments linked through ester bond.

References

    1. Langer R, Vacanti JP. Science. 1993;260:920. -PubMed
    1. Peppas NA, Hilt JZ, Khademhosseini A, Langer R. Adv Mater. 2006;18:1345.
    1. Lutolf MP, Hubbell JA. Nat Biotechnol. 2005;23:47. -PubMed
    1. Shea LD, Smiley E, Bonadio J, Mooney DJ. Nat Biotechnol. 1999;17:551. -PubMed
    1. Tirrell M, Kokkoli E, Biesalski M. Surf Sci. 2002;500:61.

Publication types

MeSH terms

Substances

LinkOut - more resources