Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse - PubMed (original) (raw)

Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse

R Felix et al. Endocrinology. 1990 Nov.

Abstract

The op/op variant of murine osteopetrosis is a recessive mutation characterized by impaired bone resorption due to lack of osteoclasts. Cultured osteoblasts and fibroblasts from this mutant do not secrete M-CSF activity and resident macrophages are absent in bone marrow. This failure has been related to a mutation within the M-CSF coding region. We report now that the administration of recombinant human M-CSF (rhM-CSF) corrects in vivo the impaired bone resorption in this animal. The treatment restores the bone marrow cavity virtually absent in the op/op animal and induces the appearance of resorbing osteoclasts and of resident bone marrow macrophages. This proves that the deficiency of M-CSF is the cause of the op/op bone disorder and that this cytokine is directly or indirectly necessary for physiological osteoclastogenesis, the resulting bone resorption and for the establishment of bone marrow hemopoiesis.

PubMed Disclaimer

Similar articles

• Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op mouse.
  Felix R, Cecchini MG, Hofstetter W, Elford PR, Stutzer A, Fleisch H. Felix R, et al. J Bone Miner Res. 1990 Jul;5(7):781-9. doi: 10.1002/jbmr.5650050716. J Bone Miner Res. 1990. PMID: 2204254
• Macrophage colony-stimulating factor restores bone resorption in op/op bone in vitro in conjunction with parathyroid hormone or 1,25-dihydroxyvitamin D3.
  Morohashi T, Corboz VA, Fleisch H, Cecchini MG, Felix R. Morohashi T, et al. J Bone Miner Res. 1994 Mar;9(3):401-7. doi: 10.1002/jbmr.5650090316. J Bone Miner Res. 1994. PMID: 8191935
• Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption.
  Niida S, Kaku M, Amano H, Yoshida H, Kataoka H, Nishikawa S, Tanne K, Maeda N, Nishikawa S, Kodama H. Niida S, et al. J Exp Med. 1999 Jul 19;190(2):293-8. doi: 10.1084/jem.190.2.293. J Exp Med. 1999. PMID: 10432291 Free PMC article.
• Role of CSF-1 in bone and bone marrow development.
  Cecchini MG, Hofstetter W, Halasy J, Wetterwald A, Felix R. Cecchini MG, et al. Mol Reprod Dev. 1997 Jan;46(1):75-83; discussion 83-4. doi: 10.1002/(SICI)1098-2795(199701)46:1<75::AID-MRD12>3.0.CO;2-2. Mol Reprod Dev. 1997. PMID: 8981367 Review.
• Macrophage differentiation and granulomatous inflammation in osteopetrotic mice (op/op) defective in the production of CSF-1.
  Naito M, Umeda S, Takahashi K, Shultz LD. Naito M, et al. Mol Reprod Dev. 1997 Jan;46(1):85-91. doi: 10.1002/(SICI)1098-2795(199701)46:1<85::AID-MRD13>3.0.CO;2-2. Mol Reprod Dev. 1997. PMID: 8981368 Review.

Cited by

• Delayed hematopoietic development in osteopetrotic (op/op) mice.
  Begg SK, Radley JM, Pollard JW, Chisholm OT, Stanley ER, Bertoncello I. Begg SK, et al. J Exp Med. 1993 Jan 1;177(1):237-42. doi: 10.1084/jem.177.1.237. J Exp Med. 1993. PMID: 8418205 Free PMC article.
• Local control of osteoclast function.
  Mundy GR. Mundy GR. Osteoporos Int. 1993;3 Suppl 1:126-7. doi: 10.1007/BF01621885. Osteoporos Int. 1993. PMID: 8461538 No abstract available.
• Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency.
  Ammann P, Rizzoli R, Bonjour JP, Bourrin S, Meyer JM, Vassalli P, Garcia I. Ammann P, et al. J Clin Invest. 1997 Apr 1;99(7):1699-703. doi: 10.1172/JCI119333. J Clin Invest. 1997. PMID: 9120014 Free PMC article.
• Hypertension meets osteoarthritis - revisiting the vascular aetiology hypothesis.
  Ching K, Houard X, Berenbaum F, Wen C. Ching K, et al. Nat Rev Rheumatol. 2021 Sep;17(9):533-549. doi: 10.1038/s41584-021-00650-x. Epub 2021 Jul 27. Nat Rev Rheumatol. 2021. PMID: 34316066 Review.
• Molecular signaling in bone cells: Regulation of cell differentiation and survival.
  Plotkin LI, Bruzzaniti A. Plotkin LI, et al. Adv Protein Chem Struct Biol. 2019;116:237-281. doi: 10.1016/bs.apcsb.2019.01.002. Epub 2019 Feb 4. Adv Protein Chem Struct Biol. 2019. PMID: 31036293 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal