Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis - PubMed (original) (raw)

Review

Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis

Amie Kim et al. J Am Diet Assoc. 2011 Nov.

Abstract

Green tea catechins (GTCs) have been studied in randomized control trials for their lipid-lowering effects. Studies, however, have been small and demonstrated conflicting results. The objective of this study was to perform a systematic review and meta-analysis of randomized controlled trials evaluating the relationship between GTCs and serum lipid levels, including total, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol, and triglycerides. A systematic literature search of MEDLINE, EMBASE, Cochrane CENTRAL, and the Natural Medicines Comprehensive Database was conducted through March 2010. Randomized controlled trials evaluating GTCs vs control in human beings and reporting efficacy data on at least one of the aforementioned serum lipid endpoints were included. Weighted mean differences for changes from baseline (with 95% confidence intervals [CIs]) for lipid endpoints were calculated using random-effects models. Twenty trials (N=1,415) met all inclusion criteria. Upon meta-analysis, GTCs at doses ranging from 145 to 3,000 mg/day taken for 3 to 24 weeks reduced total (-5.46 mg/dL [-0.14 mmol/L]; 95% CI -9.59 to -1.32) and LDL cholesterol (-5.30 mg/dL [-0.14 mmol/L]; 95% CI -9.99 to -0.62) compared to control. GTCs did not significantly alter HDL cholesterol (-0.27 mg/dL [-0.007 mmol/L]; 95% CI -1.62 to 1.09) or triglyceride (3.00 mg/dL [-0.034 mmol/L]; 95% CI -2.73 to 8.73) levels. The consumption of GTCs is associated with a statistically significant reduction in total and LDL cholesterol levels; however, there was no significant effect on HDL cholesterol or triglyceride levels.

PubMed Disclaimer

Cited by

Complementary and Integrative Health Practices Among Hispanics Diagnosed with Colorectal Cancer: Utilization and Communication with Physicians.
Black DS, Lam CN, Nguyen NT, Ihenacho U, Figueiredo JC. Black DS, et al. J Altern Complement Med. 2016 Jun;22(6):473-9. doi: 10.1089/acm.2015.0332. Epub 2016 May 10. J Altern Complement Med. 2016. PMID: 27163178 Free PMC article.
A systematic review and meta-analysis of the effects of Hibiscus sabdariffa on blood pressure and cardiometabolic markers.
Ellis LR, Zulfiqar S, Holmes M, Marshall L, Dye L, Boesch C. Ellis LR, et al. Nutr Rev. 2022 May 9;80(6):1723-1737. doi: 10.1093/nutrit/nuab104. Nutr Rev. 2022. PMID: 34927694 Free PMC article.
Quercetin and Green Tea Extract Supplementation Downregulates Genes Related to Tissue Inflammatory Responses to a 12-Week High Fat-Diet in Mice.
Cialdella-Kam L, Ghosh S, Meaney MP, Knab AM, Shanely RA, Nieman DC. Cialdella-Kam L, et al. Nutrients. 2017 Jul 19;9(7):773. doi: 10.3390/nu9070773. Nutrients. 2017. PMID: 28753942 Free PMC article.
Physical and physiological effectiveness of an overall health care program for middle-aged Japanese women with mild obesity: A pilot study.
Amano S, Tsubone H, Hanafusa M, Yamasaki T, Nishizaka S, Yanagisawa H. Amano S, et al. J Tradit Complement Med. 2015 Jan 22;5(2):88-95. doi: 10.1016/j.jtcme.2014.11.011. eCollection 2015 Apr. J Tradit Complement Med. 2015. PMID: 26151017 Free PMC article.
Dietary Polyphenols in the Prevention of Stroke.
Tressera-Rimbau A, Arranz S, Eder M, Vallverdú-Queralt A. Tressera-Rimbau A, et al. Oxid Med Cell Longev. 2017;2017:7467962. doi: 10.1155/2017/7467962. Epub 2017 Oct 24. Oxid Med Cell Longev. 2017. PMID: 29204249 Free PMC article. Review.

Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis - PubMed (original) (raw)