Neuropsychological assessment of monozygotic twins discordant for schizophrenia - PubMed (original) (raw)
Comparative Study
Neuropsychological assessment of monozygotic twins discordant for schizophrenia
T E Goldberg et al. Arch Gen Psychiatry. 1990 Nov.
Abstract
A comparison of monozygotic twins discordant for schizophrenia controls for genetic variance and reduces variance due to environmental circumstances, thus serving to highlight differences due to phenotypic-related variables. In this study, we assessed 16 such twin pairs on a wide range of neuropsychological tests. The affected twins tended to perform worse than their unaffected counterparts on most of the tests. Deficits were especially severe on tests of vigilance, memory, and concept formation, suggesting that dysfunction is greatest in the frontotemporal cortex. While manifest symptoms were not highly associated with neuropsychological scores, global level of functioning was. To address the issue of genetic liability, we also compared the sample of discordant unaffected twins with a sample of seven pairs of normal monozygotic twins. No significant differences between the groups were found for any neuropsychological test. In fact, the results suggest that neuropsychological dysfunction is a consistent feature of schizophrenia and that it is related primarily to the clinical disease process and not to genetic or nonspecific environmental factors.
Comment in
- Matching for education in studies of schizophrenia.
Resnick SM. Resnick SM. Arch Gen Psychiatry. 1992 Mar;49(3):246. doi: 10.1001/archpsyc.1992.01820030078011. Arch Gen Psychiatry. 1992. PMID: 1567279 No abstract available. - Neuropsychological performance in the unaffected twin.
Green MF. Green MF. Arch Gen Psychiatry. 1992 Mar;49(3):247. doi: 10.1001/archpsyc.1992.01820030079012. Arch Gen Psychiatry. 1992. PMID: 1567280 No abstract available.
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