Erectile dysfunction - PubMed (original) (raw)

Review

. 2013 Jan 12;381(9861):153-65.

doi: 10.1016/S0140-6736(12)60520-0. Epub 2012 Oct 5.

Affiliations

• PMID: 23040455
• DOI: 10.1016/S0140-6736(12)60520-0

Review

Erectile dysfunction

Rany Shamloul et al. Lancet. 2013.

Abstract

Erectile dysfunction is a common clinical entity that affects mainly men older than 40 years. In addition to the classical causes of erectile dysfunction, such as diabetes mellitus and hypertension, several common lifestyle factors, such as obesity, limited or an absence of physical exercise, and lower urinary tract symptoms, have been linked to the development of erectile dysfunction. Substantial steps have been taken in the study of the association between erectile dysfunction and cardiovascular disease. Erectile dysfunction is a strong predictor for coronary artery disease, and cardiovascular assessment of a non-cardiac patient presenting with erectile dysfunction is now recommended. Substantial advances have occurred in the understanding of the pathophysiology of erectile dysfunction that ultimately led to the development of successful oral therapies, namely the phosphodiesterase type 5 inhibitors. However, oral phosphodiesterase type 5 inhibitors have limitations, and present research is thus investigating cutting-edge therapeutic strategies including gene and cell-based technologies with the aim of discovering a cure for erectile dysfunction.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PubMed Disclaimer

Similar articles

• Erectile dysfunction and diabetes: a review of the current evidence-based medicine and a synthesis of the main available therapies.
  Phé V, Rouprêt M. Phé V, et al. Diabetes Metab. 2012 Feb;38(1):1-13. doi: 10.1016/j.diabet.2011.09.003. Epub 2011 Nov 4. Diabetes Metab. 2012. PMID: 22056307 Review.
• [Erectile dysfunction: how can you help?].
  Kaminsky A, Sperling H. Kaminsky A, et al. MMW Fortschr Med. 2012 Jun 21;O 154 Suppl 2:88-91; quiz 92. MMW Fortschr Med. 2012. PMID: 22916432 Review. German. No abstract available.
• [Erectile dysfunction].
  Lyngdorf P. Lyngdorf P. Ugeskr Laeger. 2002 Oct 7;164(41):4779-83. Ugeskr Laeger. 2002. PMID: 12407881 Danish. No abstract available.
• Novel therapeutic targets for erectile dysfunction.
  Williams SK, Melman A. Williams SK, et al. Maturitas. 2012 Jan;71(1):20-7. doi: 10.1016/j.maturitas.2011.11.004. Epub 2011 Dec 7. Maturitas. 2012. PMID: 22154078 Review.
• [Erectile dysfunction and cardiovascular disease].
  Urek R, Urek MC, Turek MC. Urek R, et al. Acta Med Croatica. 2006;60(1):51-3. Acta Med Croatica. 2006. PMID: 16802572 Review. Croatian.

Cited by

• Potential causal association between aspirin use and erectile dysfunction in European population: a Mendelian randomization study.
  Li R, Peng L, Deng D, Li G, Wu S. Li R, et al. Front Endocrinol (Lausanne). 2024 Jan 8;14:1329847. doi: 10.3389/fendo.2023.1329847. eCollection 2023. Front Endocrinol (Lausanne). 2024. PMID: 38260164 Free PMC article.
• "Mask up to keep it up": Preliminary evidence of the association between erectile dysfunction and COVID-19.
  Sansone A, Mollaioli D, Ciocca G, Colonnello E, Limoncin E, Balercia G, Jannini EA. Sansone A, et al. Andrology. 2021 Jul;9(4):1053-1059. doi: 10.1111/andr.13003. Epub 2021 Mar 30. Andrology. 2021. PMID: 33742540 Free PMC article.
• IL-17A exacerbates corpus cavernosum fibrosis and neurogenic erectile dysfunction by inducing CSMC senescence via the mTORC2-ACACA pathway.
  Yang W, Fang J, Zhai J, Qiu C, Liang Z, Liu Q, Wei H. Yang W, et al. BMC Med. 2024 Sep 11;22(1):376. doi: 10.1186/s12916-024-03609-3. BMC Med. 2024. PMID: 39256772 Free PMC article.
• Pomegranate juice causes a partial improvement through lowering oxidative stress for erectile dysfunction in streptozotocin-diabetic rat.
  Onal E, Yilmaz D, Kaya E, Bastaskın T, Bayatlı N, Gur S. Onal E, et al. Int J Impot Res. 2016 Nov;28(6):234-240. doi: 10.1038/ijir.2016.34. Epub 2016 Sep 1. Int J Impot Res. 2016. PMID: 27581707
• Effects of Major Antihypertensive Drug Classes on Erectile Function: a Network Meta-analysis.
  Farmakis IT, Pyrgidis N, Doundoulakis I, Mykoniatis I, Akrivos E, Giannakoulas G. Farmakis IT, et al. Cardiovasc Drugs Ther. 2022 Oct;36(5):903-914. doi: 10.1007/s10557-021-07197-9. Epub 2021 May 4. Cardiovasc Drugs Ther. 2022. PMID: 33945044

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database
  • scite Smart Citations

• Medical

  • MedlinePlus Health Information