Cognitive functioning and symptomatology in chronic schizophrenia - PubMed (original) (raw)
Cognitive functioning and symptomatology in chronic schizophrenia
H E Nelson et al. Psychol Med. 1990 May.
Abstract
Chronic schizophrenic patients in a long stay hospital were found to have low levels of intelligence (mean IQ of 80), which was attributed to the effects of substantial intellectual deterioration on below average pre-morbid levels of functioning. Patients with the lowest IQ scores had the least severe positive symptoms but symptomatology was not related to age or extent of intellectual decline. Speed of functioning was relatively more impaired than level of intellectual functioning, with cognitive speed being more affected than motor speed. The severity of negative but not positive symptoms was significantly related to the severity of bradyphrenia (cognitive slowing), a result which would be consistent with the notion of a subcortical pathology in patients with Type II schizophrenia.
Similar articles
- Neuropsychological functioning in first-episode psychosis--evidence of specific deficits.
Riley EM, McGovern D, Mockler D, Doku VC, OCeallaigh S, Fannon DG, Tennakoon L, Santamaria M, Soni W, Morris RG, Sharma T. Riley EM, et al. Schizophr Res. 2000 May 25;43(1):47-55. doi: 10.1016/s0920-9964(99)00177-2. Schizophr Res. 2000. PMID: 10828414 - A neuropsychological study of early onset schizophrenia.
Hoff AL, Harris D, Faustman WO, Beal M, DeVilliers D, Mone RD, Moses JA, Csernansky JG. Hoff AL, et al. Schizophr Res. 1996 May;20(1-2):21-8. doi: 10.1016/0920-9964(95)00065-8. Schizophr Res. 1996. PMID: 8794490 - Generalized cognitive dysfunction, symptomatology, and specific cognitive processes in relation to functioning of schizophrenia patients.
Sponheim SR, Surerus-Johnson C, Dieperink ME, Spoont M. Sponheim SR, et al. Schizophr Res. 2003 Nov 15;64(2-3):191-3. doi: 10.1016/s0920-9964(02)00524-8. Schizophr Res. 2003. PMID: 14613685 No abstract available. - A review of neuropsychological differences between paranoid and nonparanoid schizophrenia patients.
Zalewski C, Johnson-Selfridge MT, Ohriner S, Zarrella K, Seltzer JC. Zalewski C, et al. Schizophr Bull. 1998;24(1):127-45. doi: 10.1093/oxfordjournals.schbul.a033305. Schizophr Bull. 1998. PMID: 9502551 Review. - The need to integrate neuropsychological and experimental schizophrenia research.
Serper MR, Harvey PD. Serper MR, et al. Schizophr Bull. 1994;20(1):1-11; discussion 13-21. doi: 10.1093/schbul/20.1.1. Schizophr Bull. 1994. PMID: 8197408 Review.
Cited by
- Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration.
Amitai N, Markou A. Amitai N, et al. Psychopharmacology (Berl). 2009 Jan;202(1-3):275-86. doi: 10.1007/s00213-008-1246-0. Epub 2008 Jul 11. Psychopharmacology (Berl). 2009. PMID: 18618099 Free PMC article. - Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats.
Amitai N, Semenova S, Markou A. Amitai N, et al. Psychopharmacology (Berl). 2007 Sep;193(4):521-37. doi: 10.1007/s00213-007-0808-x. Epub 2007 May 12. Psychopharmacology (Berl). 2007. PMID: 17497138 - Increased impulsivity and disrupted attention induced by repeated phencyclidine are not attenuated by chronic quetiapine treatment.
Amitai N, Markou A. Amitai N, et al. Pharmacol Biochem Behav. 2009 Sep;93(3):248-57. doi: 10.1016/j.pbb.2008.08.025. Epub 2008 Sep 8. Pharmacol Biochem Behav. 2009. PMID: 18809428 Free PMC article. - The Relationship between Cognitive Decline and Psychopathology in Patients with Schizophrenia and Bipolar Disorder.
Kim MD, Seo HJ, Yun HJ, Jung YE, Park JH, Lee CI, Moon JH, Hong SC, Yoon BH, Bahk WM. Kim MD, et al. Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):103-8. doi: 10.9758/cpn.2015.13.1.103. Clin Psychopharmacol Neurosci. 2015. PMID: 25912543 Free PMC article. - Grammatical processing in schizophrenia: evidence from morphology.
Walenski M, Weickert TW, Maloof CJ, Ullman MT. Walenski M, et al. Neuropsychologia. 2010 Jan;48(1):262-9. doi: 10.1016/j.neuropsychologia.2009.09.012. Neuropsychologia. 2010. PMID: 19766129 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Medical