Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis - PubMed (original) (raw)
Review
. 2013 Jun;143(6):818-26.
doi: 10.3945/jn.112.170233. Epub 2013 Apr 17.
Affiliations
- PMID: 23596162
- DOI: 10.3945/jn.112.170233
Free article
Review
Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis
Mario Siervo et al. J Nutr. 2013 Jun.
Free article
Abstract
Diets including food products rich in inorganic nitrate are associated with lower blood pressure (BP). The evidence for the BP-lowering effects of inorganic nitrate and beetroot in randomized clinical trials has not been systematically assessed. The objective was to conduct a systematic review and meta-analysis of randomized clinical trials that examined the effects of inorganic nitrate and beetroot supplementation on BP. Medline, EMBASE, and Scopus databases were searched from inception to February 2013. The specific inclusion criteria were: 1) randomized clinical trials; 2) trials reporting effects on systolic or diastolic BP or both; and 3) trials comparing inorganic nitrate or beetroot juice supplementation with placebo control groups. Random-effects models were used to assess the pooled BP effect sizes. Sixteen trials met the eligibility criteria for the systematic review. All studies had a crossover study design. The trials were conducted between 2006 and 2012 and included a total of 254 participants with 7-30 participants/study. The duration of each intervention ranged from 2 h to 15 d. Inorganic nitrate and beetroot juice consumption were associated with greater changes in systolic BP [-4.4 mm Hg (95% CI: -5.9, -2.8); P < 0.001] than diastolic BP [-1.1 mm Hg (95% CI: -2.2, 0.1); P = 0.06]. The meta-regression showed an association between daily dose of inorganic nitrate and changes in systolic BP (P < 0.05). Inorganic nitrate and beetroot juice supplementation was associated with a significant reduction in systolic BP. These findings need to be tested in long-term trials and in individuals at greater cardiovascular risk.
Similar articles
- Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis.
Lara J, Ashor AW, Oggioni C, Ahluwalia A, Mathers JC, Siervo M. Lara J, et al. Eur J Nutr. 2016 Mar;55(2):451-459. doi: 10.1007/s00394-015-0872-7. Epub 2015 Mar 13. Eur J Nutr. 2016. PMID: 25764393 - Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects.
Jajja A, Sutyarjoko A, Lara J, Rennie K, Brandt K, Qadir O, Siervo M. Jajja A, et al. Nutr Res. 2014 Oct;34(10):868-75. doi: 10.1016/j.nutres.2014.09.007. Epub 2014 Sep 28. Nutr Res. 2014. PMID: 25294299 Clinical Trial. - Nitrate-Rich Beetroot Juice Reduces Blood Pressure in Tanzanian Adults with Elevated Blood Pressure: A Double-Blind Randomized Controlled Feasibility Trial.
Siervo M, Shannon O, Kandhari N, Prabhakar M, Fostier W, Köchl C, Rogathi J, Temu G, Stephan BCM, Gray WK, Haule I, Paddick SM, Mmbaga BT, Walker R. Siervo M, et al. J Nutr. 2020 Sep 1;150(9):2460-2468. doi: 10.1093/jn/nxaa170. J Nutr. 2020. PMID: 32729923 Free PMC article. Clinical Trial. - Ageing modifies the effects of beetroot juice supplementation on 24-hour blood pressure variability: An individual participant meta-analysis.
Siervo M, Lara J, Jajja A, Sutyarjoko A, Ashor AW, Brandt K, Qadir O, Mathers JC, Benjamin N, Winyard PG, Anning C, Shore A, Gilchrist M. Siervo M, et al. Nitric Oxide. 2015 May 1;47:97-105. doi: 10.1016/j.niox.2015.04.007. Epub 2015 Apr 29. Nitric Oxide. 2015. PMID: 25937622 - Effects of beetroot juice on blood pressure in hypertension according to European Society of Hypertension Guidelines: A systematic review and meta-analysis.
Grönroos R, Eggertsen R, Bernhardsson S, Praetorius Björk M. Grönroos R, et al. Nutr Metab Cardiovasc Dis. 2024 Oct;34(10):2240-2256. doi: 10.1016/j.numecd.2024.06.009. Epub 2024 Jun 26. Nutr Metab Cardiovasc Dis. 2024. PMID: 39069465
Cited by
- Alternative Additives for Organic and Natural Ready-to-Eat Meats to Control Spoilage and Maintain Shelf Life: Current Perspectives in the United States.
Bodie AR, Wythe LA, Dittoe DK, Rothrock MJ Jr, O'Bryan CA, Ricke SC. Bodie AR, et al. Foods. 2024 Feb 1;13(3):464. doi: 10.3390/foods13030464. Foods. 2024. PMID: 38338599 Free PMC article. Review. - Beneficial effects of inorganic nitrate/nitrite in type 2 diabetes and its complications.
Bahadoran Z, Ghasemi A, Mirmiran P, Azizi F, Hadaegh F. Bahadoran Z, et al. Nutr Metab (Lond). 2015 May 16;12:16. doi: 10.1186/s12986-015-0013-6. eCollection 2015. Nutr Metab (Lond). 2015. PMID: 25991919 Free PMC article. - Negligible Effects of Nutraceuticals from Beetroot Extract on Cardiovascular and Autonomic Recovery Response following Submaximal Aerobic Exercise in Physically Active Healthy Males: A Randomized Trial.
Benjamim CJR, de Sousa Júnior FW, Porto AA, Andrade CVG, de Figueiredo MÍLS, Benjamim CJR, da Silva Rodrigues G, Rocha EMB, Cavalcante TF, Garner DM, Valenti VE, Bueno Júnior CR. Benjamim CJR, et al. Int J Environ Res Public Health. 2023 Feb 23;20(5):4019. doi: 10.3390/ijerph20054019. Int J Environ Res Public Health. 2023. PMID: 36901028 Free PMC article. Clinical Trial. - Relation of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study.
Chan Q, Stamler J, Brown IJ, Daviglus ML, Van Horn L, Dyer AR, Oude Griep LM, Miura K, Ueshima H, Zhao L, Nicholson JK, Holmes E, Elliott P; INTERMAP Research Group. Chan Q, et al. J Hum Hypertens. 2014 Jun;28(6):353-9. doi: 10.1038/jhh.2013.115. Epub 2013 Nov 21. J Hum Hypertens. 2014. PMID: 24257514 Free PMC article. - Nutraceuticals with a clinically detectable blood pressure-lowering effect: a review of available randomized clinical trials and their meta-analyses.
Borghi C, Cicero AF. Borghi C, et al. Br J Clin Pharmacol. 2017 Jan;83(1):163-171. doi: 10.1111/bcp.12902. Epub 2016 Mar 15. Br J Clin Pharmacol. 2017. PMID: 26852373 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous