Sticky bacteriophage protect animal cells - PubMed (original) (raw)

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Sticky bacteriophage protect animal cells

Justin R Meyer. Proc Natl Acad Sci U S A. 2013.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.

Bacteriophage adherence to mucus. Ig-like properties of phage capsids (hexagon shape) adhere to glycan residues on mucin glycoproteins (branched structure) of epithelial cell’s mucus layer. Once embedded within the mucus, phage defend animal cells against invading pathogenic bacteria.

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• Bacteriophage adhering to mucus provide a non-host-derived immunity.
  Barr JJ, Auro R, Furlan M, Whiteson KL, Erb ML, Pogliano J, Stotland A, Wolkowicz R, Cutting AS, Doran KS, Salamon P, Youle M, Rohwer F. Barr JJ, et al. Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10771-6. doi: 10.1073/pnas.1305923110. Epub 2013 May 20. Proc Natl Acad Sci U S A. 2013. PMID: 23690590 Free PMC article.

References

1. 1. Levin BR, Bull JJ. Population and evolutionary dynamics of phage therapy. Nat Rev Microbiol. 2004;2(2):166–173. -PubMed
2. 1. Pirnay J-P, et al. Introducing yesterday’s phage therapy to today’s medicine. Future Virol. 2012;7(4):379–390.
3. 1. Barr JJ, et al. Bacteriophage adhering to mucus provide a non–host-derived immunity. Proc Natl Acad Sci USA. 2013;110:10771–10776. -PMC -PubMed
4. 1. Cone RA. Barrier properties of mucus. Adv Drug Deliv Rev. 2009;61(2):75–85. -PubMed
5. 1. Martens EC, Chiang HC, Gordon JI. Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont. Cell Host Microbe. 2008;4(5):447–457. -PMC -PubMed

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