Iron status and the acute post-exercise hepcidin response in athletes - PubMed (original) (raw)

Iron status and the acute post-exercise hepcidin response in athletes

Peter Peeling et al. PLoS One. 2014.

Abstract

This study explored the relationship between serum ferritin and hepcidin in athletes. Baseline serum ferritin levels of 54 athletes from the control trial of five investigations conducted in our laboratory were considered; athletes were grouped according to values <30 μg/L (SF<30), 30-50 μg/L (SF30-50), 50-100 μg/L (SF50-100), or >100 μg/L (SF>100). Data pooling resulted in each athlete completing one of five running sessions: (1) 8 × 3 min at 85% vVO2peak; (2) 5 × 4 min at 90% vVO2peak; (3) 90 min continuous at 75% vVO2peak; (4) 40 min continuous at 75% vVO2peak; (5) 40 min continuous at 65% vVO2peak. Athletes from each running session were represented amongst all four groups; hence, the mean exercise duration and intensity were not different (p>0.05). Venous blood samples were collected pre-, post- and 3 h post-exercise, and were analysed for serum ferritin, iron, interleukin-6 (IL-6) and hepcidin-25. Baseline and post-exercise serum ferritin levels were different between groups (p<0.05). There were no group differences for pre- or post-exercise serum iron or IL-6 (p>0.05). Post-exercise IL-6 was significantly elevated compared to baseline within each group (p<0.05). Pre- and 3 h post-exercise hepcidin-25 was sequentially greater as the groups baseline serum ferritin levels increased (p<0.05). However, post-exercise hepcidin levels were only significantly elevated in three groups (SF30-50, SF50-100, and SF>100; p<0.05). An athlete's iron stores may dictate the baseline hepcidin levels and the magnitude of post-exercise hepcidin response. Low iron stores suppressed post-exercise hepcidin, seemingly overriding any inflammatory-driven increases.

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Conflict of interest statement

Competing Interests: The authors would like to declare that Dorine Swinkels is associated with Hepcidin Analysis.com; however, this does not alter adherence to all the PLOS ONE policies on sharing data and materials.

Figures

Figure 1

Figure 1. Mean (± SE) pre-exercise and 3 h post-exercise hepcidin-25 levels in athletes with baseline serum ferritin levels <30 μg/L (SF<30), between 30–50 μg/L (SF30–50), between 50–100 μg/L (SF50–100), and >100 μg/L (SF>100).

* Significantly greater than SF<30. † Significantly greater than SF30–50. ‡ Significantly greater than SF50–100. ∧ Significantly greater than pre-exercise.

Figure 2

Figure 2. Scatter plot and linear trend line of each individual's 3 h post-exercise hepcidin response in association with their baseline serum ferritin levels (r = 0.52; p = 0.01).

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References

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