Influenza viruses induce autoantibodies to a brain-specific 37-kDa protein in rabbit - PubMed (original) (raw)
Influenza viruses induce autoantibodies to a brain-specific 37-kDa protein in rabbit
P Laing et al. Proc Natl Acad Sci U S A. 1989 Mar.
Abstract
Immunization of rabbits with certain H1N1 influenza viruses, including the neurotropic strains NWS/33 and WSN/33 and the New Jersey/76 strain, resulted in the production of autoantibodies to a brain-specific protein of 37 kDa that is present in various species, including humans. Autoantibodies were produced to brain only; various other tissues tested were negative. These antibodies were not elicited by other influenza A or B viruses, including closely related recombinant strains, but were elicited by the isolated hemagglutinin of A/Bellamy/42 strain and by formaldehyde-fixed WSN virus--demonstrating that infection was not essential for the induction of autoantibodies. In histological studies, reaction with anti-viral antisera was specific to gray matter and was confined to sera that recognized the 37-kDa protein. Antibody binding was prominent in regions comprised of neuronal cell bodies in cellular layers of the dentate gyrus, hippocampus, cerebral cortex, and cerebellum and was undetectable in myelin-rich regions, such as the corpus callosum. The 37-kDa protein, therefore, appears to be a neuronal antigen. Antibodies directed against this protein may be involved in the pathogenesis of one or more of the neuropsychiatric disorders that occur after infection with influenza.
Similar articles
- Strategy for the characterization of autoantigens in autoimmune diseases. Investigation of the target antigens of antimitochondrial antibodies by radioimmunoassay, immunoblotting, monoclonal antibodies and affinity chromatography.
Kyriatsoulis A, Manns M, Roth U, Gerken G, Lohse A, Wollensak S, Reske K, Meyer zum Büschenfelde KH. Kyriatsoulis A, et al. J Immunol Methods. 1988 Apr 22;109(1):113-21. doi: 10.1016/0022-1759(88)90448-6. J Immunol Methods. 1988. PMID: 3356907 - Strain-specific elements in influenza antigens.
HIRST GK. HIRST GK. J Exp Med. 1952 Dec;96(6):589-603. doi: 10.1084/jem.96.6.589. J Exp Med. 1952. PMID: 13022853 Free PMC article. - [Antigenic determinants of the hemagglutinin of influenza virus type B].
Zhumatov KKh, Isaeva EI, Kosiakov PN. Zhumatov KKh, et al. Vopr Virusol. 1983 Jul-Aug;28(4):35-9. Vopr Virusol. 1983. PMID: 6195823 Russian. - A Bivalent Heterologous DNA Virus-Like-Particle Prime-Boost Vaccine Elicits Broad Protection against both Group 1 and 2 Influenza A Viruses.
Jiang W, Wang S, Chen H, Ren H, Huang X, Wang G, Chen Z, Chen L, Chen Z, Zhou P. Jiang W, et al. J Virol. 2017 Apr 13;91(9):e02052-16. doi: 10.1128/JVI.02052-16. Print 2017 May 1. J Virol. 2017. PMID: 28179535 Free PMC article.
Cited by
- Schizophrenia and Influenza at the Centenary of the 1918-1919 Spanish Influenza Pandemic: Mechanisms of Psychosis Risk.
Kępińska AP, Iyegbe CO, Vernon AC, Yolken R, Murray RM, Pollak TA. Kępińska AP, et al. Front Psychiatry. 2020 Feb 26;11:72. doi: 10.3389/fpsyt.2020.00072. eCollection 2020. Front Psychiatry. 2020. PMID: 32174851 Free PMC article. Review. - The autoimmune model of schizophrenia.
Adams DD, Knight JG, Ebringer A. Adams DD, et al. ISRN Psychiatry. 2012 Apr 30;2012:758072. doi: 10.5402/2012/758072. Print 2012. ISRN Psychiatry. 2012. PMID: 23738211 Free PMC article. - The neuropsychiatric aspects of influenza/swine flu: A selective review.
Manjunatha N, Math SB, Kulkarni GB, Chaturvedi SK. Manjunatha N, et al. Ind Psychiatry J. 2011 Jul;20(2):83-90. doi: 10.4103/0972-6748.102479. Ind Psychiatry J. 2011. PMID: 23271861 Free PMC article. - Effects of two commonly found strains of influenza A virus on developing dopaminergic neurons, in relation to the pathophysiology of schizophrenia.
Landreau F, Galeano P, Caltana LR, Masciotra L, Chertcoff A, Pontoriero A, Baumeister E, Amoroso M, Brusco HA, Tous MI, Savy VL, Lores Arnaiz Mdel R, de Erausquin GA. Landreau F, et al. PLoS One. 2012;7(12):e51068. doi: 10.1371/journal.pone.0051068. Epub 2012 Dec 10. PLoS One. 2012. PMID: 23251423 Free PMC article. - The relationship between encephalitis lethargica and influenza: a critical analysis.
McCall S, Vilensky JA, Gilman S, Taubenberger JK. McCall S, et al. J Neurovirol. 2008 May;14(3):177-85. doi: 10.1080/13550280801995445. J Neurovirol. 2008. PMID: 18569452 Free PMC article. Review.
References
- Curr Top Microbiol Immunol. 1986;130:25-37 - PubMed
- J Gen Virol. 1968 Dec;3(3):315-26 - PubMed
- J Immunol. 1987 Aug 15;139(4):1285-90 - PubMed
- J Pediatr. 1980 Oct;97(4):535-9 - PubMed
- Proc Natl Acad Sci U S A. 1986 Dec;83(23):9254-8 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources