The effect of Stevia rebaudiana on serum omentin and visfatin level in STZ-induced diabetic rats - PubMed (original) (raw)

The effect of Stevia rebaudiana on serum omentin and visfatin level in STZ-induced diabetic rats

Samad Akbarzadeh et al. J Diet Suppl. 2015 Mar.

Abstract

Recently the role of adipocytokines in relationship to incidence of diabetes has been demonstrated. One of the medicinal plants that are used in the treatment of diabetes is stevia. This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). The animals were divided into 5 groups of 8. Rats in group 1 (non-diabetic control) and group 2 (diabetic control) were treated with distilled water, and the rats in the treated groups, group 3 (T250), group 4 (T500), and group 5 (T750) were treated with stevia, gavaged every day at 9 a.m. in doses of 250, 500, and 750 mg/kg, respectively. At the end of the study significant reductions in fasting blood sugar (FBS), the homeostasis model assessment insulin resistance (HOMA-IR), triglyceride (TG), alkaline phosphatase (ALP), and Omentin level were found in groups 3 and 4 in comparison with group 2. Pancreatic histopathology slides demonstrated that stevia extract did not induce any increase in the number of β-cells. The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats.

Keywords: Diabetes; omentin; stevia; visfatin.

PubMed Disclaimer

Cited by

Biological Assessment of Stevioside and Sucralose as Sucrose Substitutes for Diabetics on STZ-Induced Diabetes in Rats.
Barakat H, Al-Roug K, Algonaiman R, Althwab SA, Alfheeaid HA, Alhomaid RM, Almujaydil MS, Bushnaq T, Ebeid TA. Barakat H, et al. Molecules. 2023 Jan 17;28(3):940. doi: 10.3390/molecules28030940. Molecules. 2023. PMID: 36770608 Free PMC article.
Effect of stevia leaves (Stevia rebaudiana Bertoni) on diabetes: A systematic review and meta-analysis of preclinical studies.
Chowdhury AI, Rahanur Alam M, Raihan MM, Rahman T, Islam S, Halima O. Chowdhury AI, et al. Food Sci Nutr. 2022 Apr 24;10(9):2868-2878. doi: 10.1002/fsn3.2904. eCollection 2022 Sep. Food Sci Nutr. 2022. PMID: 36171777 Free PMC article. Review.
Safety of a proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: to expand the list of steviol glycosides to all those identified in the leaves of Stevia Rebaudiana Bertoni.
EFSA Panel on Food Additives and Flavourings (FAF); Younes M, Aquilina G, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Gundert-Remy U, Husøy T, Manco M, Mennes W, Moldeus P, Passamonti S, Shah R, Waalkens-Berendsen I, Wölfle D, Wright M, Degen G, Giarola A, Rincon AM, Castle L. EFSA Panel on Food Additives and Flavourings (FAF), et al. EFSA J. 2020 Apr 29;18(4):e06106. doi: 10.2903/j.efsa.2020.6106. eCollection 2020 Apr. EFSA J. 2020. PMID: 32874306 Free PMC article.
Natural Alternative Sweeteners and Diabetes Management.
Mejia E, Pearlman M. Mejia E, et al. Curr Diab Rep. 2019 Nov 21;19(12):142. doi: 10.1007/s11892-019-1273-8. Curr Diab Rep. 2019. PMID: 31754814 Review.
Effect of insulin-glucose metabolism compared with obesity on adipose omentin gene expression in different models of diabetic C57BL/6 mice.
Goodarzi G, Shirgir A, Alavi S, Khoshi A. Goodarzi G, et al. Diabetol Metab Syndr. 2019 Aug 14;11:65. doi: 10.1186/s13098-019-0460-8. eCollection 2019. Diabetol Metab Syndr. 2019. PMID: 31428203 Free PMC article.

The effect of Stevia rebaudiana on serum omentin and visfatin level in STZ-induced diabetic rats - PubMed (original) (raw)