Vitamin D insufficiency in Arabs and South Asians positively associates with polymorphisms in GC and CYP2R1 genes - PubMed (original) (raw)
Vitamin D insufficiency in Arabs and South Asians positively associates with polymorphisms in GC and CYP2R1 genes
Naser Elkum et al. PLoS One. 2014.
Abstract
Background: A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1 (DHCR7/NADSYN1) and serum levels of the active form of Vitamin D, 25 (OH) D among African Americans, Caucasians, and Chinese. Little is known about how genetic variations associate with, or contribute to, 25(OH)D levels in Arabs populations.
Methods: Allele frequencies of 18 SNPs derived from CYP2R1, GC, and DHCR7/NADSYN1 genes in 1549 individuals (Arabs, South Asians, and Southeast Asians living in Kuwait) were determined using real time genotyping assays. Serum levels of 25(OH)D were measured using chemiluminescence immunoassay.
Results: GC gene polymorphisms (rs17467825, rs3755967, rs2282679, rs7041 and rs2298850) were found to be associated with 25(OH)D serum levels in Arabs and South Asians. Two of the CYP2R1 SNPs (rs10500804 and rs12794714) and one of GC SNPs (rs1155563) were found to be significantly associated with 25(OH)D serum levels only in people of Arab origin. Across all three ethnicities none of the SNPs of DHCR7/NADSYN1 were associated with serum 25(OH)D levels and none of the 18 SNPs were significantly associated with serum 25(OH)D levels in people from South East Asia.
Conclusion: Our data show for the first time significant association between the GC (rs2282679 and rs7041), CYP2R1 (rs10741657) SNPs and 25(OH)D levels. This supports their roles in vitamin D Insufficiency in Arab and South Asian populations respectively. Interestingly, two of the CYP2R1 SNPs (rs10500804 and rs12794714) and one GC SNP (rs1155563) were found to correlate with vitamin D in Arab population exclusively signifying their importance in this population.
Conflict of interest statement
Competing Interests: The authors have declared that no competing interests exist.
Figures
Figure 1. Minor Allele Frequency of SNPs from CYP2R1, DHCR7 & GC genes between Arabs, South Asian and South East Asian ethnicities.
The standard deviation was estimated using the.
Similar articles
- Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait.
Rahman A, Abu-Farha M, Channanath A, Hammad MM, Anoop E, Chandy B, Melhem M, Al-Mulla F, Thanaraj TA, Abubaker J. Rahman A, et al. Front Endocrinol (Lausanne). 2023 Oct 20;14:1257051. doi: 10.3389/fendo.2023.1257051. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37929021 Free PMC article. - The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children.
Zhang Y, Wang X, Liu Y, Qu H, Qu S, Wang W, Ren L. Zhang Y, et al. Swiss Med Wkly. 2012 Jul 16;142:w13636. doi: 10.4414/smw.2012.13636. eCollection 2012. Swiss Med Wkly. 2012. PMID: 22801813 - Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes.
Petersen RA, Larsen LH, Damsgaard CT, Sørensen LB, Hjorth MF, Andersen R, Tetens I, Krarup H, Ritz C, Astrup A, Michaelsen KF, Mølgaard C. Petersen RA, et al. Br J Nutr. 2017 Mar;117(6):829-838. doi: 10.1017/S0007114517000538. Epub 2017 Apr 6. Br J Nutr. 2017. PMID: 28382877 - Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study.
Brouwer-Brolsma EM, Vaes AMM, van der Zwaluw NL, van Wijngaarden JP, Swart KMA, Ham AC, van Dijk SC, Enneman AW, Sohl E, van Schoor NM, van der Velde N, Uitterlinden AG, Lips P, Feskens EJM, Dhonukshe-Rutten RAM, de Groot LCPGM. Brouwer-Brolsma EM, et al. J Steroid Biochem Mol Biol. 2016 Nov;164:168-176. doi: 10.1016/j.jsbmb.2015.08.008. Epub 2015 Aug 11. J Steroid Biochem Mol Biol. 2016. PMID: 26275945 Review. - Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic review and meta-analysis.
Duan L, Xue Z, Ji H, Zhang D, Wang Y. Duan L, et al. Gene. 2018 Dec 15;678:361-369. doi: 10.1016/j.gene.2018.08.056. Epub 2018 Aug 16. Gene. 2018. PMID: 30120973 Review.
Cited by
- Genetic Variants in Vitamin-D Metabolism Genes (rs1155563, rs12785878 and rs10500804) among Females with Type-2 Diabetes Mellitus in Saudi Arabia.
Alharazy S. Alharazy S. Pak J Med Sci. 2024 Sep;40(8):1753-1758. doi: 10.12669/pjms.40.8.9318. Pak J Med Sci. 2024. PMID: 39281257 Free PMC article. - The Association Between CYP2R1 rs10741657 Polymorphisms and Bone Variables, Vitamin D, and Calcium in Iranian Children and Adolescents: A Cross-Sectional Study.
Montazeri-Najafabady N, Dabbaghmanesh MH. Montazeri-Najafabady N, et al. Biochem Genet. 2024 Jun 4. doi: 10.1007/s10528-024-10826-1. Online ahead of print. Biochem Genet. 2024. PMID: 38834820 - Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait.
Rahman A, Abu-Farha M, Channanath A, Hammad MM, Anoop E, Chandy B, Melhem M, Al-Mulla F, Thanaraj TA, Abubaker J. Rahman A, et al. Front Endocrinol (Lausanne). 2023 Oct 20;14:1257051. doi: 10.3389/fendo.2023.1257051. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37929021 Free PMC article. - Association of Vitamin D Genetic Risk Score with Noncommunicable Diseases: A Systematic Review.
Almaghrbi H, Al-Shafai M, Al-Asmakh M, Bawadi H. Almaghrbi H, et al. Nutrients. 2023 Sep 18;15(18):4040. doi: 10.3390/nu15184040. Nutrients. 2023. PMID: 37764823 Free PMC article. Review. - The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis.
Moon RJ, Green HD, D'Angelo S, Godfrey KM, Davies JH, Curtis EM, Cooper C, Harvey NC. Moon RJ, et al. Osteoporos Int. 2023 Jul;34(7):1269-1279. doi: 10.1007/s00198-023-06751-5. Epub 2023 Apr 27. Osteoporos Int. 2023. PMID: 37103591
References
- Simonelli C (2005) The role of vitamin D deficiency in osteoporosis and fractures. Minn Med 88: 34–36. - PubMed
- Borkar VV, Devidayal, Verma S, Bhalla AK (2010) Low levels of vitamin D in North Indian children with newly diagnosed type 1 diabetes. Pediatr Diabetes 11: 345–350. - PubMed
- Kilkkinen A, Knekt P, Aro A, Rissanen H, Marniemi J, et al. (2009) Vitamin D status and the risk of cardiovascular disease death. Am J Epidemiol 170: 1032–1039. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
This work was funded by Kuwait Foundation for the Advancement of Sciences. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous