Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus - PubMed (original) (raw)

Ceftobiprole- and ceftaroline-resistant methicillin-resistant Staphylococcus aureus

Liana C Chan et al. Antimicrob Agents Chemother. 2015 May.

Abstract

The role of mecA mutations in conferring resistance to ceftobiprole and ceftaroline, cephalosporins with anti-methicillin-resistant Staphylococcus aureus (MRSA) activity, was determined with MRSA strains COL and SF8300. The SF8300 ceftaroline-passaged mutant carried a single mecA mutation, E447K (E-to-K change at position 447), and expressed low-level resistance. This mutation in COL conferred high-level resistance to ceftobiprole but only low-level resistance to ceftaroline. The COL ceftaroline-passaged mutant, which expressed high-level resistance to ceftobiprole and ceftaroline, had mutations in pbp2, pbp4, and gdpP but not mecA.

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Figures

FIG 1

FIG 1

Emergence of ceftobiprole- and ceftaroline-passaged _mecA_-positive mutants. Resistance to ceftobiprole (BPR) and ceftaroline (CPT) was generated by passaging strains in subinhibitory concentrations of each antibiotic in broth. The highest concentration of drug in which strains grew each day is shown on the y axis.

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