Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis - PubMed (original) (raw)

Meta-Analysis

Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis

Liang Shen et al. Nutr J. 2015.

Abstract

Background: In recent years, the associations between vitamin D status and Alzheimer's disease (AD) and dementia have gained increasing interests. The present meta-analysis was designed to estimate the association between vitamin D deficiency and risk of developing AD and dementia.

Methods: A literature search conducted until February 2015 identified 10 study populations, which were included in the meta-analysis. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated with a random-effect model using Stata software package.

Results: Results of our meta-analysis showed that subjects with deficient vitamin D status (25(OH)D level < 50 nmol/L) were at increased risk of developing AD by 21% compared with those possessing 25(OH)D level > 50 nmol/L. Similar analysis also found a significantly increased dementia risk in vitamin D deficient subjects. There is no evidence for significant heterogeneity among the included studies.

Conclusion: Available data indicates that lower vitamin D status may be associated with increased risk of developing AD and dementia. More studies are needed to further confirm the associations and to evaluate the beneficial effects of vitamin D supplementation in preventing AD and dementia.

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Figures

Fig. 1

Fig. 1

Flowchart of selection of the references for inclusion in meta-analysis

Fig. 2

Fig. 2

Forest plot of the included studies investigating risk of developing AD in vitamin D deficient subjects. The size of each square is proportional to the study’s weight

Fig. 3

Fig. 3

Forest plot of the included studies investigating risk of developing dementia in vitamin D deficient subjects. The size of each square is proportional to the study’s weight

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