Blunted inflammation mediated by NF-κB activation in hippocampus alleviates chronic normobaric hypoxia-induced anxiety-like behavior in rats - PubMed (original) (raw)
doi: 10.1016/j.brainresbull.2016.03.001. Epub 2016 Mar 10.
Xiaofang Fan 1, Yang Li 1, Jinbin Guo 1, Dongmei Xia 1, Lu Ding 1, Qingqing Zheng 1, Wei Wang 1, Feng Xue 1, Ran Chen 1, Shouting Liu 1, Lianggang Hu 1, Yongsheng Gong 2
Affiliations
- PMID: 26972056
- DOI: 10.1016/j.brainresbull.2016.03.001
Blunted inflammation mediated by NF-κB activation in hippocampus alleviates chronic normobaric hypoxia-induced anxiety-like behavior in rats
Junming Fan et al. Brain Res Bull. 2016 Apr.
Abstract
This study aims to investigate whether inflammation mediated by NF-κB activation is involved in the induction of anxiety-like behavior in chronic normobaric hypoxia (CNH) exposed rats and to investigate the underlying mechanism. To this end, rats were exposed in a normobaric hypoxic chamber with a fraction of inspired oxygen (FIO2) of ∼ 10%, 23 h/d, continues for 2 weeks. Anxiety-like behavior was tested by elevated plus maze and open field, inflammatory response, nucleus translocation of NF-κB, and signaling pathway in hippocampus were examined. CNH induced a significant increase of anxiety- like behavior and inflammation responses, which were ameliorated by NF-κB inhibitor, PDTC pretreatment, suggesting that the anxiogenic effect induced by inflammation is through NF-κB activation. CNH treatment significantly increased nucleus translocation of p65 and p105 in hippocampus, which was suppressed by PDTC pretreatment. In addition, CNH treatment significantly increased Iba-1, iNOS, COX-2, and p-PKA in hippocampus, which were blocked by PDTC pretreatment, suggesting CNH may activate microglia cells in hippocampus through NF-κB pathway. In conclusion, our results illustrate a mechanism that, activation of NF-κB in hippocampus may trigger the proinflammatory response of microglia cells, and iNOS-PKA pathway may involve in anxiogenic effect in CNH exposed rats.
Keywords: Anxiety-like behavior; Cytokines; Hypoxia; Inflammation; Nuclear factor-κB.
Copyright © 2016 Elsevier Inc. All rights reserved.
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