Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography - PubMed (original) (raw)

Noninvasive detection of microaneurysms in diabetic retinopathy by swept-source optical coherence tomography

Sarah Cheng et al. Clin Ophthalmol. 2016.

Abstract

Background and objectives: A method of identifying retinal vascular microaneurysms (MAs) in nonproliferative diabetic retinopathy (NPDR) using swept-source optical coherence tomography (SS-OCT).

Patients and methods: SS-OCT images were acquired in 17 eyes with NPDR using prototype SS-OCT device and fluorescein angiography (FA) images were obtained simultaneously. MAs identified on SS-OCT slabs were correlated to MAs identified on FA.

Results: MAs were identified in SS-OCT slabs in 15/17 eyes, resulting in NPDR diagnosis rate of 88%. Mean number of MAs identified on FA was 11.7±11.9 (total 199) and was 8.1±9.3 (total 137) on SS-OCT. Wilcoxon rank sum test showed no significant difference in MAs detected on SS-OCT and FA (_P_=0.2995) across eyes. Wilcoxon rank sum test showed SS-OCT detected slightly fewer MAs than FA per eye (3.65 less, _P_=0.0009).

Conclusion: SS-OCT visualization of MAs could serve as a tool for diagnosing NPDR, and possibly applied as an imaging biomarker for population-based diabetic retinopathy screening.

Keywords: diabetic retinopathy; optical coherence tomography; swept-source optical coherence tomography.

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Figures

Figure 1

Figure 1

Identification of MAs on FA and SS-OCT. Notes: FA (A, C) and two of the corresponding SS-OCT slabs (average 21 slabs reviewed per eye) (B, D) of a right eye with nonproliferative diabetic retinopathy. B and D correspond to the area demarcated with the red box in A and C respectively. Representative MAs are noted with arrows in A and B. On SS-OCT, the MAs are shown as hyper-reflective dots. The SS-OCT device (Carl Zeiss Meditec, Inc., Dublin, CA, USA) used a laser wavelength centered at 1,060 nm and an acquisition speed of 100,000 A-scans/s. 3×3×3 mm3 raster scans were obtained, centered on the fovea (512 A-scans/B-scan, 512 B-scans/cube, 1,500 pixels of depth). Abbreviations: FA, fluorescein angiogram; MAs, microaneurysms; SS-OCT, swept-source optical coherence tomography.

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