DNA sequence determinants of CAP-induced bending and protein binding affinity - PubMed (original) (raw)

. 1988 Jun 30;333(6176):824-9.

doi: 10.1038/333824a0.

Affiliations

• PMID: 2838756
• DOI: 10.1038/333824a0

DNA sequence determinants of CAP-induced bending and protein binding affinity

M R Gartenberg et al. Nature. 1988.

Abstract

The sites of DNA bending induced by binding catabolite activator protein are identified and shown to coincide with positions where DNA grooves face the protein. The bendability of DNA with different sequences at these bend centres parallels the bending preference of the sequences in nucleosomal DNA. Anisotropic DNA bendability significantly affects the structure and strength of regulatory protein-DNA complexes.

PubMed Disclaimer

Similar articles

• Mode of selectivity in cyclic AMP receptor protein-dependent promoters in Escherichia coli.
  Pyles EA, Lee JC. Pyles EA, et al. Biochemistry. 1996 Jan 30;35(4):1162-72. doi: 10.1021/bi952187q. Biochemistry. 1996. PMID: 8573570
• Molecular analysis of the regulation of csiD, a carbon starvation-inducible gene in Escherichia coli that is exclusively dependent on sigma s and requires activation by cAMP-CRP.
  Marschall C, Labrousse V, Kreimer M, Weichart D, Kolb A, Hengge-Aronis R. Marschall C, et al. J Mol Biol. 1998 Feb 20;276(2):339-53. doi: 10.1006/jmbi.1997.1533. J Mol Biol. 1998. PMID: 9512707
• Determinants of DNA bending in the DNA-cyclic AMP receptor protein complexes in Escherichia coli.
  Lin SH, Lee JC. Lin SH, et al. Biochemistry. 2003 May 6;42(17):4809-18. doi: 10.1021/bi027259+. Biochemistry. 2003. PMID: 12718521
• Influence of DNA geometry on transcriptional activation in Escherichia coli.
  Déthiollaz S, Eichenberger P, Geiselmann J. Déthiollaz S, et al. EMBO J. 1996 Oct 1;15(19):5449-58. EMBO J. 1996. PMID: 8895588 Free PMC article.
• Sequence-dependent modelling of local DNA bending phenomena: curvature prediction and vibrational analysis.
  Vlahovicek K, Munteanu MG, Pongor S. Vlahovicek K, et al. Genetica. 1999;106(1-2):63-73. doi: 10.1023/a:1003724710997. Genetica. 1999. PMID: 10710711 Review.

Cited by

• The interaction of E. coli integration host factor and lambda cos DNA: multiple complex formation and protein-induced bending.
  Kosturko LD, Daub E, Murialdo H. Kosturko LD, et al. Nucleic Acids Res. 1989 Jan 11;17(1):317-34. doi: 10.1093/nar/17.1.317. Nucleic Acids Res. 1989. PMID: 2521383 Free PMC article.
• DNA sequence-specific recognition by a transcriptional regulator requires indirect readout of A-tracts.
  Mendieta J, Pérez-Lago L, Salas M, Camacho A. Mendieta J, et al. Nucleic Acids Res. 2007;35(10):3252-61. doi: 10.1093/nar/gkm180. Epub 2007 Apr 22. Nucleic Acids Res. 2007. PMID: 17452358 Free PMC article.
• Gene regulation by a glycine riboswitch singlet uses a finely tuned energetic landscape for helical switching.
  Torgerson CD, Hiller DA, Stav S, Strobel SA. Torgerson CD, et al. RNA. 2018 Dec;24(12):1813-1827. doi: 10.1261/rna.067884.118. Epub 2018 Sep 20. RNA. 2018. PMID: 30237163 Free PMC article.
• Switching control of expression of ptsG from the Mlc regulon to the NagC regulon.
  El Qaidi S, Plumbridge J. El Qaidi S, et al. J Bacteriol. 2008 Jul;190(13):4677-86. doi: 10.1128/JB.00315-08. Epub 2008 May 9. J Bacteriol. 2008. PMID: 18469102 Free PMC article.
• Large-scale inference of the point mutational spectrum in human segmental duplications.
  Nakken S, Rødland EA, Rognes T, Hovig E. Nakken S, et al. BMC Genomics. 2009 Jan 22;10:43. doi: 10.1186/1471-2164-10-43. BMC Genomics. 2009. PMID: 19161616 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Miscellaneous

  • NCI CPTAC Assay Portal