Trends in single women with malignancy of the uterine cervix in United States - PubMed (original) (raw)
Observational Study
Trends in single women with malignancy of the uterine cervix in United States
Hiroko Machida et al. J Gynecol Oncol. 2018 Mar.
Abstract
Objective: To examine trends and characteristics of single women with malignancy of the uterine cervix.
Methods: This is a retrospective observational study examining the United States population-based tumor registry (the Surveillance, Epidemiology, and End Results program). Time-specific trends in single marital status were examined in 3,294,208 women among 12 common female malignancies including 87,151 women with uterine cervical malignancy between 1973 and 2013.
Results: While the proportion of single women in the majority of malignancies increased during the study time, the proportion of single women with cervical malignancy significantly increased more than in other malignancies (29.3% in 2013 from 6.3% in 1973). There was a surge in the proportion of single women with cervical malignancy starting in the early 1990s, exhibiting the largest annual percentage rate change (APC) among all examined malignancies (1.8%; 95% confidence interval [CI]=1.6, 2.0; p<0.001). There was a significant decrease in the proportion of women aged <40 years with cervical malignancy between 1989 and 2013 (APC, -1.2%; 95% CI=-1.4, -1.0; p<0.001). However, when stratified by age, the proportion of single women aged ≥40 years increased significantly during the time (APC, 2.7%; 95% CI=2.3, 3.2; p<0.001) but did not in those who were <40 years (APC, 0.1%; 95% CI=-0.7, 0.6; p=0.850).
Conclusion: The proportion of single women with malignancy of the uterine cervix has significantly increased in the past 4 decades. This increase was most dramatic in single women aged ≥40 years. Improving screening strategies in single women aged ≥40 years may help reduce the incidence of this malignancy.
Keywords: Age Factors; Marital Status; Single Person; Trends; Uterine Cervical Neoplasms.
Copyright © 2018. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology
Conflict of interest statement
No potential conflict of interest relevant to this article was reported.
Figures
Fig. 1
Time-trends of proportion of single women and young age women in the United States. Results of piecewise linear regression analyses by Joinpoint Regression Program were shown to display temporal trends of the proportion of women with single marital status (A) and the proportion of women with aged younger than 40 years at the time of diagnosis of malignancy (B) in 12 female malignancies between 1973 and 2013 (dots represent actual observed value, and lines represent regression curves for modeled values).
Fig. 2
Temporal trends of single women in malignancy of the uterine cervix stratified by patient age. Proportions of younger single women (aged <40 years) (yellow line) and older single women among women (aged ≥40 years) (blue line) are shown per calendar year. Dots represent percent and error bar represent 95% confidence interval.
References
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