Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress - PubMed (original) (raw)

Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress

Kusum K Kharbanda et al. Biomolecules. 2018.

Abstract

The symposium, "Role of Nutrition in Alcoholic Liver Disease", was held at the European Society for Biomedical Research on Alcoholism Congress on 9 October 2017 in Crete, Greece. The goal of the symposium was to highlight recent advances and developments in the field of alcohol and nutrition. The symposium was focused on experimental and clinical aspects in relation to the role of different types of dietary nutrients and malnutrition in the pathogenesis of alcoholic liver disease (ALD). The following is a summary of key research presented at this session. The speakers discussed the role of dietary fats and carbohydrates in the development and progression of alcohol-induced multi-organ pathology in animal models of ALD, analyzed novel nutrition-related therapeutics (specifically, betaine and zinc) in the treatment of ALD, and addressed clinical relevance of malnutrition and nutrition support in ALD. This summary of the symposium will benefit junior and senior faculty currently investigating alcohol-induced organ pathology as well as undergraduate, graduate, and post-graduate students and fellows.

Keywords: alcoholic liver disease; betaine; carbohydrates; fat; malnutrition; nutrition; nutritional support in ALD; zinc.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

Figure 1

Elevated levels of polyunsaturated fatty acid (PUFA) metabolites in liver injury caused by acute-on-chronic ethanol administration. (A) Plasma alanine aminotransferase (ALT) levels were significantly higher in mice fed ethanol and unsaturated fat compared to ethanol and dietary saturated fat; (B) oxidized metabolites of linoleic acid; (C) oxidized metabolites of arachidonic acid. SF: saturated fat; EtOH: ethanol-fed; USF: unsaturated fat; HODE: hydroxyoctadecadienoic acids; HETE: hydroxyeicosatetraenoic acids; * p < 0.05.

Figure 2

Figure 2

Effects of gestational second-hand smoke (SHS) on body weight and liver pathology in male C57BL/6 mice fed chow or pair-fed Lieber DeCarli liquid diets at up to 28% ethanol calories for 16 weeks beginning on post-natal day 65. PF: pair-fed dextrose/maltodextran. a < b < c, significantly different at p < 0.05.

Figure 3

Figure 3

Time-course handgrip assessment in patient with moderate alcoholic hepatitis. (A) Correlation analysis between hand grip response and Model for End-Stage Liver Disease (MELD) score; (B) hand grip dynamometry.

References

    1. De Minicis S., Brenner D.A. Oxidative Stress in Alcoholic Liver Disease: Role of NADPH Oxidase Complex. J. Gastroenterol. Hepatol. 2008;23(Suppl. 1):S98–S103. doi: 10.1111/j.1440-1746.2007.05277.x. -DOI -PubMed
    1. Ambade A., Mandrekar P. Oxidative stress and inflammation: Essential partners in alcoholic liver disease. Int. J. Hepatol. 2012;2012:853175. doi: 10.1155/2012/853175. -DOI -PMC -PubMed
    1. Dey A., Cederbaum A.I. Alcohol and oxidative liver injury. Hepatology. 2006;43(Suppl. 1):S63–S74. doi: 10.1002/hep.20957. -DOI -PubMed
    1. Purohit V., Abdelmalek M.F., Barve S., Benevenga N.J., Halsted C.H., Kaplowitz N., Kharbanda K.K., Liu Q.Y., Lu S.C., McClain C.J., et al. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: Summary of a symposium. Am. J. Clin. Nutr. 2007;86:14–24. doi: 10.1093/ajcn/86.1.14. -DOI -PubMed
    1. Kharbanda K.K., Mailliard M.E., Baldwin C.R., Beckenhauer H.C., Sorrell M.F., Tuma D.J. Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. J. Hepatol. 2007;46:314–321. doi: 10.1016/j.jhep.2006.08.024. -DOI -PubMed

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