Postmitotic Fate Refinement in the Subplate - PubMed (original) (raw)
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Postmitotic Fate Refinement in the Subplate
Mohammed A Mostajo-Radji et al. Cell Stem Cell. 2018.
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Abstract
How is the astonishing diversity of cortical neurons specified? In this issue of Cell Stem Cell, Ozair et al. (2018) leverage hPSC neural differentiation to show that projection neurons undergo prolonged sojourns in the subplate before migrating to deep layers, suggesting that pausing in the subplate may enable integration of intrinsic and extrinsic cues during postmitotic fate refinement.
Copyright © 2018 Elsevier Inc. All rights reserved.
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- hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate.
Ozair MZ, Kirst C, van den Berg BL, Ruzo A, Rito T, Brivanlou AH. Ozair MZ, et al. Cell Stem Cell. 2018 Jul 5;23(1):60-73.e6. doi: 10.1016/j.stem.2018.05.024. Epub 2018 Jun 21. Cell Stem Cell. 2018. PMID: 29937203
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