Integrative/Hybrid Methods Structural Biology: Role of Macromolecular Crystallography - PubMed (original) (raw)

Review

Integrative/Hybrid Methods Structural Biology: Role of Macromolecular Crystallography

Stephen K Burley. Adv Exp Med Biol. 2018.

Abstract

Macromolecular crystallography has been central to the emergence and development of structural biology as a scientific discipline. Approximately 90% of the more than 138,000 three-dimensional structures currently available in the Protein Data Bank (PDB) archive, the single, global open access data resource for macromolecular structure data, were determined using X-ray crystallography. MX, the enormous variety of PDB structures of proteins, DNA, and RNA, and computational models derived therefrom will be central to the growth of integrative or hybrid (I/H) methods structural studies of macromolecular assemblies and other complex biological systems.

Keywords: 3D structure; Atomic coordinates; DNA; I/H methods; Integrative/hybrid methods; MX; Macromolecular crystallography; PDB; Protein; Protein crystallography; Protein data Bank; RNA; Structural biology; Worldwide protein data Bank; X-ray crystallography; wwPDB.

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