Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis - PubMed (original) (raw)

Review

. 2019 Jul;39(3):275-282.

doi: 10.1055/s-0039-1685515. Epub 2019 May 17.

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Review

Novel Drivers of the Inflammatory Response in Liver Injury and Fibrosis

Alexander Wree et al. Semin Liver Dis. 2019 Jul.

Abstract

Hepatocyte demise as well as signals released by stressed hepatocytes have been now recognized as important triggers of liver inflammation. While traditional concepts classically viewed hepatocyte cell death to occur by either a nonlytic, noninflammatory form (apoptosis), or lytic, proinflammatory nonregulated cell death (necrosis), recent studies have provided evidence for additional mechanisms that can contribute to both acute and chronic liver damage. Two novel forms of cell death, pyroptosis and necroptosis, are of particular importance as they are highly regulated and intrinsically proinflammatory. Additionally, stressed hepatocytes may also release signals to attract and activate monocytes into proinflammatory macrophages. In this review, the authors discuss recent developments supporting the role of novel triggers of liver inflammation in various forms of liver injury and their potential translational implications.

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